Arthritis/ Gout/ Hyper uricemia Facts

Question 1

NSAID action

Answer 1

-anti-inflamm, reduction of PGE 2 and prostacyclin prevents vasodilation and inflammatory cells
-Analgesic effect, Loss of prostacyclin sensitization to pain soup
-antipyretic effect, Prevent IL-1 releasing prostaglandins in the CNS elevation the hypothalamic set point

Question 2

COX-1

Answer 2

constitutive COX that plays role in mucus production and platelet aggregation
-Has platelet activating effects

Question 3

COX-2

Answer 3

inducible form that deals with inflammatory mediators
-has platelet inhibiting effects
-found in CNS can lead to confusion if inhibited

Question 4

COX-2 selective thrombosis

Answer 4

From selectivity to COX-2 only Platelet activation takes place