Influenza drugs Flashcards
Amantadine
inhibit proton channel function in type A preventing decapsidation of gene material
Rimantadine
inhibit proton channel function in type A preventing decapsidation of gene material
-closes open, seals closed
——–
-type A influenza
——–
-resistance from M2 proton channel mutation
Oseltamivir
/
specific viral neuraminidase inhibitor
——-
-resistant type A and B
——–
Zanamivir
/
specific viral neuraminidase inhibitor analog for sialic acid
——-
-resistant type A and B
——–
Peramivir
/
neuraminidase inhibitor
——–
-influenza
Xofluza
Prodrug of baloxavir
inhibits mRNA replication by inhibiting endonuclease of viral POL
——–
-reduces duration by 1.5days
Remdesivir
/
inhibits RNA dep RNA pol to cause chain termination
——-
-ebola, RSV, influenza
molnupiravir
Integrated into DNA as G then mutates to A causing mutation and deactivation of influenza
Nirmatrelvir
part of paxlovid
peptidomimetic protease inhibitor
Ritonavir
part of paxlovid
protease inhibitor and CTP3A4 inhibitor to increase activity