Influenza drugs Flashcards

1
Q

Amantadine

A

inhibit proton channel function in type A preventing decapsidation of gene material

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2
Q

Rimantadine

A

inhibit proton channel function in type A preventing decapsidation of gene material
-closes open, seals closed
——–
-type A influenza
——–
-resistance from M2 proton channel mutation

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3
Q

Oseltamivir

A

/
specific viral neuraminidase inhibitor
——-
-resistant type A and B
——–

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4
Q

Zanamivir

A

/
specific viral neuraminidase inhibitor analog for sialic acid
——-
-resistant type A and B
——–

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5
Q

Peramivir

A

/
neuraminidase inhibitor
——–
-influenza

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6
Q

Xofluza

A

Prodrug of baloxavir
inhibits mRNA replication by inhibiting endonuclease of viral POL
——–
-reduces duration by 1.5days

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7
Q

Remdesivir

A

/
inhibits RNA dep RNA pol to cause chain termination
——-
-ebola, RSV, influenza

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8
Q

molnupiravir

A

Integrated into DNA as G then mutates to A causing mutation and deactivation of influenza

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9
Q

Nirmatrelvir

A

part of paxlovid
peptidomimetic protease inhibitor

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10
Q

Ritonavir

A

part of paxlovid
protease inhibitor and CTP3A4 inhibitor to increase activity

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