Endocrine disorders and prostate cancer facts

Question 1

Short negative feedback

Answer 1

Secretions from the AP feedback to the Hypothalamus

Question 2

Long negative feedback

Answer 2

secretions from the periphery feed back to the AP or hypothalamus

Question 3

Growth hormone

Answer 3

stimulated by GHRF from HT, high till 4yo then at puberty drops off more
-deficiency can lead to dwarfism
-used to treat turners syndrome
-used for body mass

Question 4

GH receptor

Answer 4

class 1 cytokine receptor
-simultaes insulin like growth factor (IGF) which is anabolic

Question 5

Insulin like growth factor receptor (IGF-1)

Answer 5

Stimulates cell growth
-activates Ras and cell proliferation
-activates Akt which leads to mTOR

Question 6

somatostatin

Answer 6

Acts on the pituitary to reduce GH release

Question 7

Androgen stimulation of hair growth

Answer 7

Stimulate growth on face, chest and back
but inhibit growth on scalp