Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm 233 > Chemo drugs > Flashcards

Chemo drugs Flashcards

1
Q

Cyclophosphamide

A

Nitrogen mustard alkylating agent
Given IV but not active till liver conversion
——–
-Breast
-lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Procarbazine

A

/
Triazine/Tetrazine alkylating agent
——-
-lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Platinums

A

Group of Alkylating agents
-Cisplatin (lung)
-Carboplatin (lung)
-Oxaliplatin (colon)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Methotrexate

A

Antimetabolite folate antagonist preventing purine synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Fluorouracil

A

antimetabolite uracil analog which inhibits thymidylate synthetase
-build up of dUMP causes DNA damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cytarabine

A

*/
antimetabolite which inhibits DNA polymerase
——
-Leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Mercaptopurine

A

-leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Other pyrimidine analogs

A

Fluorouracil (colon, breast)
Cytarabine (Leukemia)
Capectiabine (colon,breast)
Gemcitabine (lung)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pemetrexed

A

/
antimetabolite folate antagonist
——
-lung

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Doxorubicin

A

Anthracycline topoisomerase inhibitors
p53 activator, causes apoptosis and tumour suppression
——
-breast
-lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Other anthracyclines

A

topoisomerase inhibitors
Idarubicin (leukaemia)
Epirubicin (breast)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Etoposide

A

-lung
-lymphoma
——-
-cardio toxicity
-GI damage (nausea)
-BM suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Irinotecan

A

-colon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Paclitaxel

A

-Breast
-lung
——-
-BM suppression
-Neurotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Prednisolone

A

/
Glucocorticoid inhibiting lymphocyte proliferation
——-
-leukemias
-lymphoma
—–

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tamoxifen

A

Antioestrogen, prevents hormone dependent breast cancer
-Blocks oestrogen receptors
——–
-breast cancer

17
Q

Antiandrogens

A

-prostate tumors

18
Q

Aromatase inhibitors

A

Anastrozole, letrozole, exemestane
prevent oestrogen production
——-
-breast cancer in post menopause

19
Q

Vinca alkaloids

A

antimicrotubules
-vincristine (lymphoma, breast)
-Vinblastine (lymphoma)
-Vinorelbine (breast, lung)

20
Q

Taxanes

A

Antimicrotubules
-paclitaxel (breast, lung)
-docetaxel (breast, prostate)
Nab-Paclitaxel (Breast)

21
Q
A

Pharm 233 (57 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions