Cell wall and folic acid inhibitors drugs

Question 1

Sulfonamides

Answer 1

Folic acid inhibitor
-competitivley inhibit DHPS
——-
- anti biotic
-Broad spec?
——-
-Hepatitis
-Stevens johnson
-Bone marrow depression
-Acute renal failure
-Cyanosis

Question 2

Folic acid antagonists

Answer 2

Folate pteridine analogs
-inhibit DHFR
———
-Anti biotic
-Combined with sulfonamides
——-
-Folate deficiency
-Megaloblastic anemia

Question 3

Penicillins

Answer 3

B-lactam
- irreversibly inhibit PBP
——-
-anti biotics
——
-hypersensitivity
-proconvusant (pen G intrathecal)

Question 4

Beta lactamase inhibitors

Answer 4

Clavulanic acid and sulbactam
mixed with amoxicillin to increase efficacy

Question 5

Cephalosporins

Answer 5

B-lactam
-Wide distribution (brain)
——
-pneumonia
-renal infections
——–
-nephrotoxicity
-Alcohol tolerance
-Bone marrow depression
-Cross allergy with penicllins

Question 6

Carbapenems

Answer 6

/
B-lactams but bind to different PBP location
——-
-very broad spectrum
——
-Neurotoxicity
-Seizures (imipenem)

Question 7

Cilastatine

Answer 7

renal dipeptidase inhibitor to decrease metabolism of Imipenem

Question 8

Monobactams

Answer 8

B-lactam
-specific for PBP3
——-
-cystic fibrosis
——-
-well tolerated

Question 9

Glycol/lipo peptides

Answer 9

/
Inhibit transglycosylase and transpeptidase prevent NAM and NAG cross link.
——-
-MRSA
-C difficile
-only negative bacteria
——
-ototoxicity
-nephrotoxicity
-Flushing
-neutropenia

Question 10

Polymixin

Answer 10

/
Binds phosphate group in membrane to disrupt integrity
——-
-Negative spec
-Topical only
——–
-nephrotoxicity

Question 11

Fosfomycin

Answer 11

/
inhibits MurA which prevents cell wall synthesis
—–
-UTI
——
-well tolerated