Antimycobacterials drugs

Question 1

Isoniazid

Answer 1

/
Prodrug actives by katG inhibits mycolic acids
——
-TB
——
-hemolytic anemia if glucose 6 deficient

Question 2

Rifampicin

Answer 2

/
inhibits prokaryotic RNA pol
—–
-TB
——
-acute interstitial nephritis
-orange dye to fluids

Question 3

Ethambutol

Answer 3

/
likely inhibits arabinosyl transferase preventing cell wall synthesis
—-
-TB
—–
-optic neuritis
-peripheral neuropathy

Question 4

Pyrazinamide

Answer 4

/
analog of nicotinamide and taken up into lysosomes then activated and inhibit fatty acid synthase
——
-TB
——
-gout (prevent secretion)
-hepatic damage

Question 5

Capreomycin

Answer 5

/
bind 70s subunit to inhibit protein synthesis
——-
-TB
——-
-renal damage
-auditory nerve injury

Question 6

Cycloserine

Answer 6

/
prevents NAM side chains preventing peptidoglycan synthesis
——
-TB
——–
-

Question 7

Bedauiline

Answer 7

inhibit ATP synthase in mito
new drug for resistant TB

Question 8

Delamanid

Answer 8

inhibits mycolic acid production
prodrug activated by nitroreductase
new drug for resistant TB

Question 9

Dapsone

Answer 9

/
inhibits folate synthesis (like sulfonamides)
—–
-leprosy
——
-hemolysis of RBC
-methemoglobinemia
-Lepra reaction (makes it worse)

Question 10

Clofazimine

Answer 10

/
somehow stops DNA in leprosy bacilli
——-
-leprosy
——-
-reddish colour of skin and body fluids but turns lesions blue