Bone disorders facts Flashcards

1
Q

aminobisphosphonate MOA

A

inhibit osteoclasts via inhibition of mevalonate pathway which messes up signalling and causes apoptosis

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2
Q

Non-aminobisphosphonates MOA

A

cause build up of cytotoxic agents in osteoclasts causing cell death

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3
Q

Bisphosphonate contraindictions

A

-low blood calcium
-poor renal function

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4
Q

selective estrogen receptor modulators (SERMs)

A

stimulate osteoblasts and inhibit osteoclasts

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5
Q

PTH

A

low levels cause bone deposition
high levels cause bone reabsorption and renal elim of phosphates

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6
Q

Vitamin D

A

regulator of calcium and phosphate works along side PTH

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7
Q

Vitamin D receptor

A

intracellular receptors regulating gene transcription

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8
Q

RANKL

A

Receptor activator of nuclear factor kappa ligand, binding to RANK increases osteoclast activity

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9
Q

Calcitonin

A

When Ca gets too high can decrease retention and cause deposition binding directly to osteoclasts to inhibit them

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