Bone disorders facts Flashcards
aminobisphosphonate MOA
inhibit osteoclasts via inhibition of mevalonate pathway which messes up signalling and causes apoptosis
Non-aminobisphosphonates MOA
cause build up of cytotoxic agents in osteoclasts causing cell death
Bisphosphonate contraindictions
-low blood calcium
-poor renal function
selective estrogen receptor modulators (SERMs)
stimulate osteoblasts and inhibit osteoclasts
PTH
low levels cause bone deposition
high levels cause bone reabsorption and renal elim of phosphates
Vitamin D
regulator of calcium and phosphate works along side PTH
Vitamin D receptor
intracellular receptors regulating gene transcription
RANKL
Receptor activator of nuclear factor kappa ligand, binding to RANK increases osteoclast activity
Calcitonin
When Ca gets too high can decrease retention and cause deposition binding directly to osteoclasts to inhibit them