Helminth drugs

Question 1

Benzimidazoles

Answer 1

/
prevents B-tubulin polymerization preventing glucose uptake
———
-pinworm
-whipworm
-common roundworm
-commom and American hookworm
——-
-GI upset

Question 2

Nitazoxanide

Answer 2

tizoxanide prodrug
-inhibits PFOR preventing energy metabolism
——
-Giardiasis
-Cryptosporidiosis
—–
-

Question 3

Praziquantel

Answer 3

/
-binds consensus PKC sites in beta subunit of schistosome VG calcium channels and opens them causing influx and muscle contraction
——-
-Flukes
-onchocerciasis
——–
-dizziness
-abdominal distress

Question 4

Piperazine

Answer 4

/
GABA agonist causing hyperpolariztion and paralysis
——-
-common roundworm
-threadworm
——–
-urticaria
-seizures

Question 5

Pyrvinium

Answer 5

/
interferes with glucose uptake by binding mitochondrial complex 1
——-
-Pin worms only
——
-GI upset

Question 6

Diethylcarbamazine

Answer 6

/
Proposed MOA: alters surface membrane to make immune system attack via arachidonate metabolism
——–
-elephantiasis
-Roundworm
-threadworm
——-
-hypersensitivity from products produced by dying filariae

Question 7

Niclosamide

Answer 7

/
Depolarizes inner mito membrane preventing energy metabolism
——-
-Fish, dwarf and beef tapeworm
—–
-Pruritis

Question 8

Levamisole

Answer 8

/
nicotine like, active neuromuscular block
——
-common roundworm
——-
-agranulocytosis (has been withdrawn(

Question 9

Ivermectin

Answer 9

/
Opens glutamate chloride channels, also binds GABA or nAChR causing motor paralysis
——-
-Filarial infections
-onchocerciasis
-round worms
——
-rash/itch
-Encephalopathy