Protein synthesis targeters drugs

Question 1

Tetracyclines

Answer 1

Reversibly inhibit 16s subunit
-no food with these
——
- broad spec
-meningitis
——–
-Staining of teeth
-hypoplasia
-Bone deformities
- Very toxic with expired

Question 2

Aminoglycosides

Answer 2

/
Irreversibly inhibit 30S subunit or open pores in membrane
——
-aerobic bacteria
- gram neg
——-
-Ototoxicity (no way out of ear)
-nephrotoxicity
-neuromuscular block

Question 3

Macrolides

Answer 3

/
Bind 23s subunit and prevent peptide chain growth
——
-similar spec to penicillins
——-
-Cholestatic jaundice if Tx >3w

Question 4

Chloramphenicol

Answer 4

/
Same as macrolides Bind 23s subunit and prevent peptide chain growth
——
-wide spec
-use for resistant strains
——
-pancytopenia from bone marrow depression
-grey baby syndrome

Question 5

Oxazolidinones

Answer 5

Linezolid only synthetic antibiotic
-prevent tRNA binding to 70S
- Weak MOA inhibitor
——–
-positive spec
-MRSA
——
-thrombocytopenia
-serotonin syndrome
-hyperlactatemia

Question 6

Fusidic acid

Answer 6

/
-steroid that inhibits translation
——-
-postive bacteria
——
-jaundice

Question 7

Streptogramins

Answer 7

/
cyclic peptide to inhibit 50S
——
-postive spec
-must be IV
——
-arthralgia
-myalgia

Question 8

Dalfopristin

Answer 8

Binds to ribosome and increases binding for the streptogramin quinupristin

Question 9

Lincosamide (clindamycin)

Answer 9

Macrolide MOA, binding 23s
-take with lots of water
——
-conjunctivitis
——-
-can increase psudeomembranous colitis

Question 10

Quinolones

Answer 10

/
Bind gyrase and topoisomerase 4
—–
-broad spec
——-
-arthropathy
-convulsions (with theophylline)