Anti acids drugs Flashcards by Ethan Nieuwenhout | Brainscape

Q

Cimetidine

A

H2 receptor antagonist
-reduce cAMP levels inhibiting proton pumps
-inhibits histamine and Gastrin
—
-Lower stomach pH
-heal gastric and duodenal ulcers
—
-thrombocytopenia
-gynaecomastia, galactorrhea
-decreased sex drive in men

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Q

Ranitidine

A

H2 receptor antagonist
-reduce cAMP levels inhibiting proton pumps
-inhibits histamine and Gastrin
—
-Lower stomach pH
-heal gastric and duodenal ulcers
—
-thrombocytopenia
-gynaecomastia, galactorrhea

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Q

Nizatidine

A

H2 receptor antagonist
-reduce cAMP levels inhibiting proton pumps
-inhibits histamine and Gastrin
—
-Lower stomach pH
-heal gastric and duodenal ulcers
—
-thrombocytopenia
-gynaecomastia, galactorrhea

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Q

Famotidine

A

H2 receptor antagonist
-reduce cAMP levels inhibiting proton pumps
-inhibits histamine and Gastrin
—
-Lower stomach pH
-heal gastric and duodenal ulcers
—
-thrombocytopenia
-gynaecomastia, galactorrhea

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Q

Omeprazole

A

PPI
-irreversibly bind PP reducing H+ in lumen
-take 30-60min before meal
-2-3 day effect
—
-Ulcers
-GERD
—
-Hypergastrinemia (covers decreased pH in stomach due to cancer growth)

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Q

esomeprazole

A

PPI
-irreversibly bind PP reducing H+ in lumen
-take 30-60min before meal
-2-3 day effect
—
-Ulcers
-GERD
—
-Hypergastrinemia (covers decreased pH in stomach due to cancer growth)

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Q

Lansoprazole

A

PPI
-irreversibly bind PP reducing H+ in lumen
-take 30-60min before meal
-2-3 day effect
—
-Ulcers
-GERD
—
-Hypergastrinemia (covers decreased pH in stomach due to cancer growth)

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Q

Pantoprazole

A

PPI
-irreversibly bind PP reducing H+ in lumen
-take 30-60min before meal
-2-3 day effect
—
-Ulcers
-GERD
—
-Hypergastrinemia (covers decreased pH in stomach due to cancer growth)

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Q

Rabeprazole

A

PPI
-irreversibly bind PP reducing H+ in lumen
-take 30-60min before meal
-2-3 day effect
—
-Ulcers
-GERD
—
-Hypergastrinemia (covers decreased pH in stomach due to cancer growth)

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Q

Misoprostol

A

Analogue of Prostaglandin E1
EP1/2/3/4 agonist
-inhibits ECL cells to reduce secretion
-repairs mucus barrier
—
-Ulcers
-Low stomach pH
—
-Uterine contractions (avoid during pregnancy)

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Q

Magnesium hydroxide

A

Antacids
-salts that react with H+ to neutralize stomach
—
-ulcers
-GERD
—
-Belching
-bloating
-diarrhea

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Q

Aluminum hydroxide

A

Antacids
-salts that react with H+ to neutralize stomach
—
-ulcers
-GERD
—
-Belching
-bloating
-constipation

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Q

Simeticone

A

Anti foaming agent used for antacids
-prevents bloating and flatulence from carbonate antacids

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Q

Bismuth Chelate

A

-Forms protective barrier over ulcers
-increases prostaglandins, mucus and bicarbonate
-inhibits bacterial proteolytic enzymes
—
-Ulcers
-GERD
—
-Black tongue and faces
-tinnitus
-Reye’s syndrome if renal function is impaired

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Q

Sucralfate

A

Aluminum hydroxide and sulfated sucrose to form antacid gel in stomach
-forms positively charged layer for ulcer
-inhibits pepsin
-prostaglandin stimulation
—
Ulcers
—
-constipation
-don’t mix with PPI or antacid

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