Anti acids Facts

Question 1

Stimulants of parietal cell acid

Answer 1

histamine, gastrin, acetylcholine

Question 2

inhibitors of parietal cell acid

Answer 2

Prostaglandin E2/I2
somatostatin

Question 3

G cells

Answer 3

secrete gastrin

Question 4

enterochromaffin like cells

Answer 4

neuroendocrine cells secrete histamine

Question 5

D cell

Answer 5

secrete somatostatin

Question 6

mucus secreting cell

Answer 6

create protective barrier from mucin and HCO3 (keeps surface at pH=6-7

Question 7

Peptic ulcers

Answer 7

caused by H. pylori inducing inflammation which stimulates G cells to secrete gastrin which increases acidity and cancer risk due to ECH cell proliferation

Question 8

H2 receptor

Answer 8

On parietal cells activates cAMP levels which stimulates more acid secretion

Question 9

PPI MOA

Answer 9

They are weak bases that accumulate in canaliculi which bind and irreversibly inhibit proton pumps

Question 10

EP2/3 receptor

Answer 10

on parietal cells binds to E1 or misoprostol decreasing acid secretion

Question 11

EP4 receptor

Answer 11

simulates mucin production is stomach activated by misoprostol

Question 12

EP1/2 receptor

Answer 12

stimulates bicarbonate production in stomach activated by misoprostol

Question 13

magnesium effect

Answer 13

causes diarrhea

Question 14

aluminum effect

Answer 14

constipation