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Pharm 233 > Gi motility drugs > Flashcards

Gi motility drugs Flashcards

1
Q

Bisacodyl

A

Stimulant laxative
-increases secretion and peristalsis
—
-Constipation
—
-atonic colon

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2
Q

Sodium picosulfate

A

Stimulant laxative
-increases secretion and peristalsis
—
-Constipation
—
-atonic colon

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3
Q

Senna

A

Stimulant laxative
-increases secretion and peristalsis
—
-Constipation
—
-atonic colon

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4
Q

Dantron

A

Stimulant laxative
-increases secretion and peristalsis
—
-Constipation
—
-atonic colon

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5
Q

Methylcellulose

A

Bulk laxative
-increases peristalsis and aids consistency
—
-constipation
—
with high FODMAP
-bloating
-flatulence

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6
Q

sterculia

A

Bulk laxative
-increases peristalsis and aids consistency
—
-constipation
—
with high FODMAP
-bloating
-flatulence

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7
Q

Agar bran

A

Bulk laxative
-increases peristalsis and aids consistency
—
-constipation
—
with high FODMAP
-bloating
-flatulence

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8
Q

Ispaghula husk

A

Bulk laxative
-increases peristalsis and aids consistency
—
-constipation
—
with high FODMAP
-bloating
-flatulence

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9
Q

Magnesium salts

A

Osmotic laxatives
-increase osmotic pressure drawing water in to lumen
—
-constipation
-purge within an hour
—
-contraindicated with impaired renal function

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10
Q

Lactulose

A

osmotic laxative
semisynthetic fructose and galactose
-increases osmotic pressure
—
-constipation
-takes 2-3 days to work
—
-cramps
-flatulence
-diarrhea

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11
Q

Polyethylene glycol (PEG)

A

Osmotic laxative
-increases osmotic pressure, also immobilizes water in lumen
-doesn’t effect stool weight or transit time
—
-constipation
—
-nausea
-abdominal upset

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12
Q

Lubiprostone

A

Chloride channel 2 agonist
-promotes secretion
—
-opioid constipation
—
-nausea

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13
Q

Naloxegol

A

Mu opioid receptor antagonist
-Is peglated to prevent CNS absorption
—
-opioid constipation
—
-

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14
Q

Prucalopride

A

5-HT4 receptor agonist
-increases propulsive activity
—
-Used when other drugs fail for constipation
—

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15
Q

Codeine

A

Opioid
-activation of opioid receptors slowing peristalsis and secretion
—
-diarrhea
—
-dependance
-resp. failure

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16
Q

Loperamide

A

Mu opioid receptor agonist
-inhibits peristalsis
-increases sphincter tone
-Low CNS effects
—
-diarrhea
—
-constipation
-paralytic ileum (disc after 5d

17
Q

Diphenoxylate

A

Mu opioid receptor agonist
-inhibits peristalsis
-increases sphincter tone
-Low CNS effects
—
-diarrhea
—
-constipation
-paralytic ileum (disc after 5d

18
Q

Racecadotril

A

Prodrug of thiorphan
-inhibits enkephalinase
-enkephalins activate delta receptors lowing secretion
—
-diarrhea
-use with rehydration
—
-Itch

19
Q

Bismuth Subsalicylate

A

Pepto contains clays
-act as bulk forming
-also anti secretory
—
-diarrhea
—
-black tongue
-reyes syndrome

20
Q

Eluxadoline

A

-Mu and kappa agonist Delta antagonist
-slows transit
—
-IBS diarrhea
—

21
Q

Linaclotide

A

synthetic peptide
-increases cGMP by guanylate cyclase C
-increases Cl- + HCO3 secretion
—
-IBS constipation

22
Q

Methotrexate

A

Folic acid antagonist inhibiting DNA synthesis
-inhibits dihydrofolate reductase (DHFR)
—
-anti inflammatory for IBS/IBD
—
-blood issues
-liver cirrhosis

23
Q

Sulfasalazine

A

-bound to 5-ASA delivers to large intestine
-lowers inflammation
—
-anti inflammatory for IBS/IBD
—
-Sulfa drug allergy

24
Q

Cyclosporine

A

cyclic peptide immunosuppressant
-inhibits calcineurin
-inhibits cyclophilin
—
-immunosuppressant/ anti inflammatory for IBS/IBD
—
-nephrotoxicity
-hepatotoxicity
-hypertension
-increased infection chance

25
Q

Azathioprine

A

Prodrug of mercaptopurine immunosuppressant
-inhibits DNA synthesis
—
-immunosuppressant/ anti inflammatory for IBS/IBD
—
-bone marrow depression

26
Q

infliximab

A

Biologic
-antibody against TNF alpha
—
-anti inflammatory for IBS/IBD
—
-

27
Q

Adalimumab

A

biologic
-antibody against TNF alpha
—
-anti inflammatory for IBS/IBD
—

28
Q

Golimumab

A

biologic
-antibody against TNF alpha
—
-anti inflammatory for IBS/IBD
—

29
Q

Vedolizumab

A

biologic
-antibody against Alpha 4 beta 7 on HTc
-prevents binding and activation with mucosal cells
—
-anti inflammatory for IBS/IBD
—

30
Q

Ustekinumab

A

biologic
-antibody against p40 subunit of IL-12 and IL-23
—
-anti inflammatory for IBS/IBD

Pharm 233 (57 decks)

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