Rheumatology Flashcards
Axial Spondyloarthritis (axSpA)
= a long-term inflammatory arthritis affect the spine and other joints, tendons and ligaments
What are the (8) symptoms of Axial spondyloarthritis (axSpA)?
- Low back pain (that starts before the age of 35-45 years and has lasted at least 3 months)
- Associated night pain
- Buttock pain
- Symptoms that improve when you move around
- Symptoms that improve with non-steroidal anti-inflammatory drugs (NSAIDs) - e.g, ibuprofen and aspirin
- A close relative with spondyloarthritis
- Associated with other type of arthritis (e.g., psoriasis)
- Pain or swelling in the joints not caused by an injury
What is Rheumatoid arthritis?
- affects body’s immune system by attacking cells that line the joint and causes them to become inflamed (Arthritis Research UK 2008)
- can limit motion and lead to damage of the joints, cartilage and nearby bone
What are the risk factors for Rheumatoid arthritis?
- genetic
- more prevalent in people over 65 year olds (most likely develop between 30-50)
- women are 3x more likely than men to be affected
- smoking
- infection or trauma
How does Rheumatoid arthritis affect patients?
- Worry about becoming progressively disabled
- Stop working sooner than expected (financial impact)
- Be less independent
- Experience changes in relationships
- Worry about having additional children if diagnosed young
- Feel isolated
- Become depressed
What is Osteoarthritis?
- degenerative joint disease in which tissues in the joints (i.e, cartilage, tendons, ligaments, synovium, bone) break down over time
- small bone growths (called osteophytes or bone spurs) may grow on edges of the joint
What are the risk factors for Osteoarthritis?
- more common with age
- women are more likely to develop than men (especially after age 50)
- younger people can develop due to sport injury, abnormal joint structure and genetic defect in joint cartilage
What fraction of Rheumatoid arthritis patients have major depression?
1/6
What fraction of Osteoarthritis patients report depression symptoms when the pain is the worst?
2/3
What is Rheumatology?
covers wide range of conditions affecting the musculoskeletal system
What are some examples of rheumatic diseases?
- Microscopic polyangitis
- Henoch-Schonlein Purpura
- Systemic lupus erythematosus
- Familial fever syndromes
- Scleroderma
- Polymyositis
- Dermatomyositis
- Acute rheumatic fever
- Lyme disease
- Rheumatic consequences of HIV infection
- Polymyalgia rheumatica
- Giant cell arteritis
- Polyarteritis
- Takayasu arteritis
- Granulomatosis with polyangitis
- Sjogren syndrome
- Fibromyalgia
- Gout
- Pseudogout
- Osteoarthritis
- Rheumatoid Arthritis
- Ankylosing spondylitis
- Psoriatic arthritis
- Reactive arthritis
- Post-infection arthritis
- Eosinophilic granulomatosis with polyangitis
- Behcet syndrome
- Cryoglobulinaemic vasculitis
Systemic Lupus Erythematosus (SLE)
a chronic autoimmune disease that can lead to inflammation and tissue damage in many parts of the body - skin, joints, heart, lungs, kidneys and brain
What are (11) common symptoms of Systemic Lupus Erythematosus (SLE)?
- Arthritis – affecting two or more joints, causing stiffness and pain
- Extreme fatigue and weakness
- Malar (butterfly) rash over the cheeks – often photosensitive
- Oral/nasal ulcers
- Hair loss
- Flu-like symptoms and/or night sweats
- Inflammation of the tissues covering the internal organs (serositis) with associated chest and/or abdominal pain
- Haematological disorders including anaemia
- Kidney problems, often first seen as proteinuria
- Seizures, mental illness or other cerebral problems
- Headaches, migraine
What are the (10) symptoms of Ehlers-Danlos Syndrome (most commonly Hypermobile EDS)?
- Focal and generalised joint pain (including dislocations)
- Muscle spasms, muscle weakness, ‘restless legs’
- Fatigue
- Poor sleep
- Anxiety
- Gastrointestinal disorders (e.g. IBS, reflux, disordered gut motility)
- Fragile/stretchy skin, poor wound healing, hernias, easy bruising
- Headaches, brain fog, poor memory, poor concentration
- Palpitations
- Bladder/pelvic floor problems
What causes gout?
- sedentary lifestyle and obesity
- harmful products
- kidneys don’t excrete uric acid (this builds u in joints and crystalises)