Pain Flashcards
How much more common is depression for those with persistent pain?
4x more common
What % of people with chronic pain will have another significant medical problem (i.e.: a co-morbidity)?
87%
What is pain?
an unpleasant sensory and emotional experience associated with actual or potential tissue damage
Noxious
poisonous or harmful
Hyperalgesia
heightened pain intensity as a response to noxious stimuli
Analgesia
absence of pain or inability to feel pain
Dysaesthesia
abnormal sensation felt when touched, caused by damage to peripheral nerves
Paraesthesia
abnormal sensation with no apparent physical cause (e.g.: tingling, pricking, chilling, burning or numb sensation)
Allodynia
innocuous (harmless) stimuli cause pain
Hyperpathia
exaggerated responses to painful stimuli
What is the physiology of pain?
- An irritation or injury is detected in the peripheral nervous system by special nerves (nociceptors).
- A nerve impulse is then generated, sending a pain impulse towards the CNS.
- The message is received by the brain where the extent and significance of the irritation or injury is interpreted, and pain is sensed.
What are nociceptors?
free nerve endings present in every tissue in the body except for the brain, which are activated by noxious stimuli
What are examples of noxious stimuli?
- Thermal: severe heat or cold
- Mechanical: trauma, disease, injury, hypoxia, ulceration, infection, peripheral nerve damage, inflammation, ischaemia
- Chemical: histamine, kinins, prostaglandins, which are released due to tissue damage and inflammation
What are the 3-linked neurones that make up the ascending pathway of pain?
- First-order neurons
- Second-order neurons
- Third-order neurons
What are first-order neurons?
travel from the nociceptors to the spine