Pharmacology - Chapter 92 - Antiviral Agents 2 - Drugs for HIV Infection and Related Opportunistic Infections

Question 1

HIV causes __.

Answer 1

AIDS.

Question 2

HIV promotes Immunodeficiency by killing CD 4 T Lymphocytes. T/F?

Answer 2

True!

Question 3

AIDS begins with…

Answer 3

CD4 T Cell counts below 200 cells/ml, or an AIDS defining illness, like Pneumonia, TB, etc.

Question 4

HIV is a retrovirus. T/F?

Answer 4

True!

Question 5

What are the classes of Antiretroviral Drugs?

Answer 5

Reverse Transcriptase Inhibitors - suppress synthesis of Viral DNA (Nucleoside - Zidovudine Retrovir) and (Non-nucleoside - Nevirapine/ Viramune) and PROTEASE Inhibitors (Indinavir - Crixivan).

Question 6

What does Zidovudine (Retrovir) do?

Answer 6

Inhibits HIV replication.

Question 7

What are some AE’s of Zidovudine?

Answer 7

Anemia, Neutropenia, Lactic Acidosis, Gastrointestinal Effects.

Question 8

What are some adverse effects of Protease inhibitors?

Answer 8

Hyperglycemia, Fat redistribution, hyperlipidemia, Reduced bone density, hepatoxicity, drug interactions, etc.