Pharmacology - Chapter 100 - Basic Principles of Cancer Chemoterhapy

Question 1

Mortality form infectious diseases has declined, but cancer has emerged as a leading cause of death. T/F?

Answer 1

True!

Question 2

in 2002, _____ Americans died from Cancer.

Answer 2

555,500

Question 3

Cell Cycle and Cancer - G1 Phase

Answer 3

to make DNA.

Question 4

Cell Cycle and Cancer - S Phase

Answer 4

DNA Synthesis.

Question 5

Cell Cycle and Cancer - G2 Phase

Answer 5

Prepares for Cell Division

Question 6

Cell Cycle and Cancer - M Phase

Answer 6

Cell Division

Question 7

Cell Cycle and Cancer - Cancer

Answer 7

unregulated cellular proliferation (from alterations in their DNA.)

Question 8

Cancer - def

Answer 8

unregulated cellular proliferation (from alterations in their DNA.)

Question 9

What are the drug classes for cancer treatment?

Answer 9

Cytotoxic Agents, Hormones, Immunotherapy.

Question 10

Treating Hodkin’s Lymphoma - Drugs

Answer 10

Doxorubicin + Bleomycin + Dacarbazine

Question 11

Treating Burkitt’s Lymphoma - Drugs

Answer 11

Cyclosphosphamode + Vincristine + Methotrexate + Doxorubicin + Prednisone

Question 12

Treating Choriocarcinoma - drugs

Answer 12

Methotrexate +/- Leucovorin

Question 13

Small Lung Cancer - drugs

Answer 13

Etoposide + Either Cisplatin or Carboplatin

Question 14

Testicular Cancer - drugs

Answer 14

Dactinomycin + Vincristine +/- Doxorubicine +/- Cyclophosphamide

Question 15

Acute Lumphocytic Leujomia - drugs.

Answer 15

Vincristine + Prednisone + Asparaginase + Daunorubicine or Doxorubicine +/- Cycluphosphamide.

Question 16

Chemotherapy drugs are more toxic to tissues with ___ growth factors.

Answer 16

High Growth Factors, like bone marrow, skin, hair follicles, sperm, gastrointestinal tract.

Question 17

Intermittent Chemo - def

Answer 17

allows normal cells to repopulate between rounds of treatment.

Question 18

Combination Chemo - def

Answer 18

suppress drug resistance, increase cell kill, reduce injury to normal cells.

Question 19

What is regional drug delivery?

Answer 19

Intra-arterial (high concentration in the area of the tumor) intrathecal (direct injection in subarachnoid space - bypasses blood brain barrier) and Intracavity.