Pharmacology - Chapter 100 - Basic Principles of Cancer Chemoterhapy Flashcards
Mortality form infectious diseases has declined, but cancer has emerged as a leading cause of death. T/F?
True!
in 2002, _____ Americans died from Cancer.
555,500
Cell Cycle and Cancer - G1 Phase
to make DNA.
Cell Cycle and Cancer - S Phase
DNA Synthesis.
Cell Cycle and Cancer - G2 Phase
Prepares for Cell Division
Cell Cycle and Cancer - M Phase
Cell Division
Cell Cycle and Cancer - Cancer
unregulated cellular proliferation (from alterations in their DNA.)
Cancer - def
unregulated cellular proliferation (from alterations in their DNA.)
What are the drug classes for cancer treatment?
Cytotoxic Agents, Hormones, Immunotherapy.
Treating Hodkin’s Lymphoma - Drugs
Doxorubicin + Bleomycin + Dacarbazine
Treating Burkitt’s Lymphoma - Drugs
Cyclosphosphamode + Vincristine + Methotrexate + Doxorubicin + Prednisone
Treating Choriocarcinoma - drugs
Methotrexate +/- Leucovorin
Small Lung Cancer - drugs
Etoposide + Either Cisplatin or Carboplatin
Testicular Cancer - drugs
Dactinomycin + Vincristine +/- Doxorubicine +/- Cyclophosphamide
Acute Lumphocytic Leujomia - drugs.
Vincristine + Prednisone + Asparaginase + Daunorubicine or Doxorubicine +/- Cycluphosphamide.
Chemotherapy drugs are more toxic to tissues with ___ growth factors.
High Growth Factors, like bone marrow, skin, hair follicles, sperm, gastrointestinal tract.
Intermittent Chemo - def
allows normal cells to repopulate between rounds of treatment.
Combination Chemo - def
suppress drug resistance, increase cell kill, reduce injury to normal cells.
What is regional drug delivery?
Intra-arterial (high concentration in the area of the tumor) intrathecal (direct injection in subarachnoid space - bypasses blood brain barrier) and Intracavity.