Pharmacology - Chapter 31 - Antipsychotic Agents

Question 1

Antipsychotic Agents are …

Answer 1

a chemically diverse group of compounds employed to treat a broad spectrum of psychotic disorders.

Question 2

Antipsychotic Agents are …

Answer 2

a chemically diverse group of compounds employed to treat a broad spectrum of psychotic disorders.

Question 3

Tourette’s Syndrome - def

Answer 3

neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics.

Question 4

Huntington’s Chorea - def

Answer 4

a fatal inherited disorder with no cure - progressive loss of mental functioning due to brain cell death.

Question 5

What are the two major groups of Anti-psychotic agents?

Answer 5

Typical/Conventional Antipsychotics and Atypical/Nonconventional Antipsychotics

Question 6

Typical/Conventional - block __ receptors.

Answer 6

Dopamine receptors.

Question 7

Typical/Conventional antipsychotics - can cause…

Answer 7

EPS - movement disorders.

Question 8

Atypical/Nonconventional - stronger blockade of ___ receptors.

Answer 8

Serotonin - risk of EPS is low.

Question 9

Schizophrenia - characterized by..

Answer 9

Disordered thinking, reduced ability to comprehend reality, and usually emerges by adolescence or early childhood.

Question 10

Positive symptoms - def

Answer 10

addition - like delusions, agitation, tension, paranoia.

Question 11

Negative Symptoms - def

Answer 11

loss or lessening of normal function - like lack of motivation, poor self care, social withdrawal.

Question 12

Schizophrenia - after florid symptoms, like hallucinations, one has…

Answer 12

suspiciousness, poor anxiety management, diminished judgment, diminished self care, etc.

Question 13

The exact etiology of Schizophrenia is known. T/F?

Answer 13

False - it is not known.

Question 14

Conventional Antipsychotics - __ potency, ___ potency, and ___ potency.

Answer 14

Low (Thorazine)/Med (Loxatine)/High (Haldol.)

Question 15

Consequence of Blocking - D2 Dopaminergic Receptor

Answer 15

EPS/Prolactin Release.

Question 16

Consequence of Blocking - H1 Histamine

Answer 16

Sedation

Question 17

Consequence of Blocking - Muscarinic Cholinergic

Answer 17

Dry mouth, blurred vision, urinary retention, constipation, tachycardia.

Question 18

Consequence of Blocking - Alpha 1- Adrenergic

Answer 18

Orthostatic Hypotension, Reflex Tachycardia

Question 19

Consequence of Blocking - 5-HT2

Answer 19

Weight Gain.

Question 20

Tourette’s Syndrome - def

Answer 20

neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics.

Question 21

Huntington’s Chorea - def

Answer 21

a fatal inherited disorder with no cure - progressive loss of mental functioning due to brain cell death.

Question 22

What are the two major groups of Anti-psychotic agents?

Answer 22

Typical/Conventional Antipsychotics and Atypical/Nonconventional Antipsychotics

Question 23

Typical/Conventional - block __ receptors.

Answer 23

Dopamine receptors.

Question 24

Typical/Conventional antipsychotics - can cause…

Answer 24

EPS - movement disorders.

Question 25

Atypical/Nonconventional - stronger blockade of ___ receptors.

Answer 25

Serotonin - risk of EPS is low.

Question 26

Schizophrenia - characterized by..

Answer 26

Disordered thinking, reduced ability to comprehend reality, and usually emerges by adolescence or early childhood.

Question 27

Positive symptoms - def

Answer 27

addition - like delusions, agitation, tension, paranoia.

Question 28

Negative Symptoms - def

Answer 28

loss or lessening of normal function - like lack of motivation, poor self care, social withdrawal.

Question 29

Schizophrenia - after florid symptoms, like hallucinations, one has…

Answer 29

suspiciousness, poor anxiety management, diminished judgment, diminished self care, etc.

Question 30

The exact etiology of Schizophrenia is known. T/F?

Answer 30

False - it is not known.

Question 31

Conventional Antipsychotics - __ potency, ___ potency, and ___ potency.

Answer 31

Low (Thorazine)/Med (Loxatine)/High (Haldol.)

Question 32

Consequence of Blocking - D2 Dopaminergic Receptor

Answer 32

EPS/Prolactin Release.

Question 33

Consequence of Blocking - H1 Histamine

Answer 33

Sedation

Question 34

Consequence of Blocking - Muscarinic Cholinergic

Answer 34

Dry mouth, blurred vision, urinary retention, constipation, tachycardia.

Question 35

Consequence of Blocking - Alpha 1- Adrenergic

Answer 35

Orthostatic Hypotension, Reflex Tachycardia

Question 36

Consequence of Blocking - 5-HT2

Answer 36

Weight Gain.