Pharmacology - Chapter 64 - Androgens

Question 1

Androgen Hormones are produced by…

Answer 1

testes, ovaries, adrenal cortex.

Question 2

What is the major androgen prototype?

Answer 2

Testosterone

Question 3

What does testosterone do?

Answer 3

Promotes expression of male sex characters and influence female sex characters.

Question 4

Testosterone is made by ___ ___ of the testes. Production is influenced by ___ and __.

Answer 4

Leydig Cells/ FSH/LH.

Question 5

In female, preandrogens are secreted by…

Answer 5

adrenal cortex and ovaries.

Question 6

Androgens - what do they do in males?

Answer 6

Pubertal transformation, spermatogenesis.

Question 7

Testosterone and Testosterone Esters -

Answer 7

testosterone.

Question 8

17-alpha-alkylated compounds.

Answer 8

Fluoxymesterone, Methyltestosterone.

Question 9

Misc. androgens -

Answer 9

danazol, Testolactone.

Question 10

Anabolic Steroids - taken by…

Answer 10

Athletes.

Question 11

What are some common drugs taken that are Anabolic Steroids?

Answer 11

Nandrolone (Durabolin), Stanozol (Winstrol), Methenolone.

Question 12

What are some therapeutic uses of Androgens?

Answer 12

Male hypogonadism, Delayed Puberty, Breast Cancer, replacement therapy in menopausal women, wasting syndrome (gradual loss of androgens and muscle mass) in Aids patients, Hereditary angioedema (localized swelling of subcutaneous tissue), Anemia.

Question 13

What are some AE’s of Androgens?

Answer 13

Virilization, Hepatotoxicity, Low HDL, Premature Epiphyseal Closure, Edema, Gynecomastia (breast enlargement in males.)