Pharmacology - Chapter 69 - Antihistamines

Question 1

Histamine - def

Answer 1

endogenous compound found in specialized cells (basophils and bast cells.) They regulate allergic responses and regulate gastric acid secretion.

Question 2

Release of histamine is influenced by…

Answer 2

Allergic and non-allergic conditions.

Question 3

(Allergic Release) Histamine is the production of antibodies of the ____ in response to specific allergens.

Answer 3

IgE.

Question 4

(Non-allergic release) - a number of agents can act directly on ___ cells to cause histamine release.

Answer 4

mast cells.

Question 5

Histamine acts through 2 types of receptors - which are…

Answer 5

H1 and H2.

Question 6

H1 receptor - causes…

Answer 6

vasodilation, increased capillary permeability, and bronchoconstriction.

Question 7

H2 receptor - causes…

Answer 7

secretion of gastric acid.

Question 8

What are the two types of Antihistamines?

Answer 8

H1 Receptor Antagonists and H2 Receptor Antagonists

Question 9

What are the therapeutic uses of antihistamines?

Answer 9

Mild allergies, severe allergies, motion sickness, insomnia, and the common cold.

Question 10

What are the 5 types of H1 Antagonists? (First Generation, Sedating)

Answer 10

Alkylamines (Dimetapp), Ethanolamines (Benadryl), Ethylenediamines (PBZ), Phenothiazines (Phenergan), Piperidines (Phenergan)

Question 11

What is the one type of non-sedating second generation H1 Antagonist?

Answer 11

Azelastine (Astelin)