Pharmacology - Chapter 91 - Antifungal Agents

Question 1

What are the two major groups of antifungal disease?

Answer 1

Systemic Mycotic (fungal) infections, which are much less frequent and more dangerous.
Superficial Mycotic (fungal) infection.

Question 2

What are the two types of Systemic Mycotic infections?

Answer 2

Opportunistic and Non-opportunistic.

Question 3

Opportunistic - primarily in….

Answer 3

debilitated and immunocompromised hosts.

Question 4

Systemic mycotic (fungal) infections are easy to treat. T/F?

Answer 4

False - they are difficult to treat!

Question 5

What are the four classes of systemic antifungal drugs?

Answer 5

Polyenes, Azoles, Pyrimidine Analogs, Echinocandins.

Question 6

Amphotericin B (Fungizone) - it is a ___ spectrum fungal agent that is used for..

Answer 6

Broad spectrum/systemic mycoses.

Question 7

Fungistatic - def

Answer 7

inhibits the synthesis of ergosterol, which is an essential component of the fungal cytoplasmic membrane, which causes leakage, etc.

Question 8

What are some adverse effects of the Azole group of antifungal agents?

Answer 8

Nausea, Headache, Vomiting, Abdominal pain.

Question 9

Superficial mycoses are caused by two groups of fungi -

Answer 9

Candida Species and Dermatophytes