Pharmacology - Chapter 70 - Nonsteroidal Anti-inflammatory Drugs (NSAID's) and Acetaminophen Flashcards
What do these drugs do?
Inhibit Cycloozygenase (which helps synthesize prostaglandins and related compounds which promotes inflammation and sensitize receptors to painful stimuli.)
What are these drugs used for?
Suppress inflammation, relieve pain, reduce fever.
What are some adverse effects of these drugs?
Gastric ulceration, bleeding, and acute renal failure.
Cycloozygenase has 2 forms -
Cox 1 (Good-cox) - found in all tissues and Cox 2 (Bad cox) found at sites of tissue injury.
Cox 1 - mediates ____, protects ___ mucosa, supports ___ function, promotes ___ aggregation.
housekeeping chores, protects gastric mucosa, supports renal function, promotes platelet aggregation.
Cox 2 - mediates ____ and sensitizes receptors to ___ stimuli.
Inflammation/painful.
NSAID’s - two types.
FIrst Generation (Inhibit both cox 1 and cox 2) - ASPIRIN.
Second Generation (Inhibit Cox 2 only) - celecoxib.
What is the drug without inflammatory properties?
Acetaminophen
Aspirin - a nonselective COX inhibitor. T/F?
True!
Aspirin - suppression of platelet aggregation. T/F?
True!
What are some adverse effects of Aspirin?
Gastrointestinal, bleeding, renal impairment, salicylism (headache, sweating, dizziness, etc.), Reye Syndrome (children - overdose, encephalopathy and fatty liver degeneration), hypersensitivity reaction.
2nd Generation Cox-2 inhibitor (selective) (CELEBREX) - Uses
osteoarthritis, rheumatoid arthritis.
Adverse effects of Celebrex (Cox 2 Inhibitor, Second Generation)
Dyspepsia (abdominal discomfort), Abdominal Pain, renal toxicity
What does Tylenol do?
Analgesic, Antipyretic
What is the action of Tylenol?
Inhibits prostaglandin in synthesis in central nervous system.
