Pharmacology - Chapter 62 - Drugs for Infertility

Question 1

Infertility - def

Answer 1

decrease in the ability to reproduce.

Question 2

Sterility - def

Answer 2

Complete absence of reproductive ability.

Question 3

Female infertility can result from any phase of the reproductive process - T/F?

Answer 3

True!

Question 4

What are some causes of female infertility?

Answer 4

Anovulation and failure of follicular maturation, unfavorable cervical mucus, luteal-phase defect, endometriosis, androgen excess, etc.

Question 5

Male infertility comes from….

Answer 5

Impotence, Idiopathic.

Question 6

What is the objective of treating female infertility?

Answer 6

Maturation of ovarian follicles, ovulation, production of favorable cervical mucus, control of endometriosis, reduction of excessive prolactin levels, etc.

Question 7

Clomiphene (Clomid) - used to promote…

Answer 7

Follicular maturation and ovulation. It blocks receptors for estrogen, too.

Question 8

What are some AE’s of Clomiphene (Clomid) ?

Answer 8

Gastrointestinal, Visual disturbances, ovarian enlargement.

Question 9

Bromocriptin (Parlodel) - used to correct…

Answer 9

amenorrhea and infertility due to excessive prolactin.

Question 10

What are some AE’s of Bromocriptine (Parlodel)?

Answer 10

Nausea, Headache, Dizziness.

Question 11

Donazol (Danocrine) - used to treat…

Answer 11

endometriosis and associated infertility.

Question 12

How does Donazol work?

Answer 12

Reduces synthesis of ovarian hormone, suppresses release of FSH and LH, blocks hormone receptors on endometrial implants.

Question 13

What are some AE’s of Donazol?

Answer 13

May induce virilization (acne, deep voice, facial hair, etc.)