Pharmacology - Chapter 55 - Hematopoietic Growth Factors Flashcards
Hematopoietic Growth Factors - act on…
bone marrow to stimulate formation of blood cells.
What are the therapeutic applications for hematopoietic growth factors? (3)
Acceleration of neutrophil population after cancer therapy, acceleration of bone marrow recovery after bone marrow transplant, stimulation of erythrocyte production in patient with chronic renal failure.
What are the types of Hematopoietic Growth Factor?
RBC’s, WBC’s - types are…Erythropoietin Granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF)
Thrombopoietic Growth Factor - ____.
Platelets.
Epoetin Alfa (Epogen) - what is it?
Hematopoietic growth factor produced by recombinant DNA technology.
What is Epoetin Alfa (Epogen) used for?
Chronic Renal failure, HIV infected patients, Chemotherapy.
What is the adverse effect of Epoetin Alfa (Epogen?)
Hypertension!
Filgrastim (G-CSF or GM-CSF?)
G-CSF
Filgrastim (Neupogen)- what is it?
Hematopoietic grwoth factor produced by Recombinant DNA technology.
What is Filgrastim (Neupogen) used for?
Chemo, bone marrow transplant, Chronic neutropenia (lack of neutrophils.)
What is the adverse effect of Filgrastim (Neupogen) ?
Bone pain.
Sargramostim - GM-CSF - T/F?
True!
What is Sagramostim? What does it do?
Granulocyte-Macrophase Colony Stimulatin Factor. increased production of neutrophils, monocytes, macrophages and eosinophils.
What is Sagramostim used for?
Adjunct to autologus bone marrow transplantation.
What is the adverse effect of Sagramostim?
Bone pain.
