Chapter 19 - Indirect-Acting Antiadrenergic Agents

Question 1

Indirect-Acting Antiadrenergic Agents - what do they do?

Answer 1

prevents stimulation of peripheral adrenergic receptors.

Question 2

What are the two groups of indirect acting antiadrenergic drugs?

Answer 2

Adrenergic neuron blocking agents (decrease NE release) and Centrally acting alpha agonists (reduce impulses along the sympathetic nerves.)

Question 3

Adrenergic Neuron-Blocking Agent - drug

Answer 3

Resperine (Rauwolfia) - used for hypertension. Depletes Ne from post ganglionic sympathetic neuron synthesis.

Question 4

Adrenergic Neuron Blocking Agents - what does it do, specifically?

Answer 4

slows heart rate and reduces cardiac output. Sedaction.

Question 5

Adrenergic Neuron Blocking Agents - what are these specifically used for?

Answer 5

Hypertension, Psychotic states - except used rarely now for this.

Question 6

Adrenergic Neuron Blocking Agents - adverse effects -

Answer 6

depression, bradycardia, increase acid formation in stomach and increase peristalsis.

Question 7

Centrally acting alpha agonists - drug

Answer 7

Clonidine - selective stimulation of alpha receptors. Used for hypertension.

Question 8

Investigation uses of Centrally Acting Alpha 2 Agonists - 4

Answer 8

Migraines, menopausal flushing, opioid withdrawal, tourette’s syndrome

Question 9

Centrally Acting Alpha 2 Agonists - adverse effects

Answer 9

Drowsiness, Xerostomia (dry mouth), rebound hypertension, embryotoxic