Pharmacology - Chapter 58 - Drugs Related to Hypothalamic and Pituitary Function

Question 1

The ___ and ___ are two parts of the brain - which have important roles in integrating the nervous and endocrine system.

Answer 1

Hypothalamus/Pituitary.

Question 2

The hypothalamus is the communication link and regulates the secretions of various hormones by controlling the pituitary gland. T/F?

Answer 2

True!

Question 3

The __ gland releases hormones that control many of the endocrine system’s functions.

Answer 3

Pituitary.

Question 4

Anterior Pituitary Releases……

Answer 4

Growth Hormone, Corticotropin, Thyrotropin, FSH, Luteinizing Hormone, Prolactin

Question 5

Posterior Pituitary Releases…

Answer 5

Oxytocin, ADH

Question 6

Growth Hormone - def

Answer 6

stimulates growth in practically all tissues and organs.

Question 7

Corticotropin - def

Answer 7

Acts on adrenal cortex to promote synthesis and release of adrenocortical hormones.

Question 8

Thyrotropin - def

Answer 8

acts on thyroid gland to promote synthesis and release of thyroid hormone.

Question 9

FSH - def

Answer 9

acts on ovaries to promote follicular growth and development. In the testes, FSH promotes spermatogenesis.

Question 10

Luteinizing hormone - def

Answer 10

acts in women to promote ovulation and development of the corpus luteum. In men, LH acts on testes to promote androgen production.

Question 11

Prolactin - def

Answer 11

stimulates milk production after parturtion.

Question 12

Oxytocin - def

Answer 12

facilitate uterine contractions at term.

Question 13

ADH - def

Answer 13

promotes renal conversation of water.

Question 14

What does growth hormone do?

Answer 14

Promotes growth, promotes protein synthesis and carbohydrate metabolism.

Question 15

Dwarfism - def

Answer 15

Growth hormone deficiency.

Question 16

Acromegaly - def

Answer 16

Growth hormone excess.

Question 17

How do we treat Dwarfism?

Answer 17

Growth hormone replacement, including the drugs Somatrem (Protropin) and Somatropin (Humatrope.)

Question 18

Somatrem - what are some AE’s?

Answer 18

Hyperglycemia, hypothyroidism, Antibody formation, and it costs so much!

Question 19

Acromegaly - How do we treat it?

Answer 19

Surgery, Radiation, Somatostatin

Question 20

Octerotide (Sandostatin) -

Answer 20

Synthetic analog of somatostatin, suppresses growth hormone release.

Question 21

What are some AE’s of Octreotide (Sandostatin) ?

Answer 21

Gastrointestinal, Gallstones.

Question 22

ADh Promotes renal __ of water.

Answer 22

Conservation.

Question 23

ADh deficiency produces ___ diabetes -

Answer 23

Hypothalmic diabetes.

Question 24

How do we treat ADH deficiencies?

Answer 24

Desmopression.

Question 25

Drugs used for diabetes insipidus?

Answer 25

Vasopressin, Desmopressin, Lypressin

Question 26

Vaso/Desmo/Lyp - AE’s -

Answer 26

water intoxication, vasoconstriction.