Pharmacology - Chapter 50 - Drugs for Angina Pectoris

Question 1

Angina Pectoris - what is it?

Answer 1

Sudden pain beneath the sternum often radiating to left shoulder and arm.

Question 2

Angina Pectoris - caused when…

Answer 2

oxygen demand is greater than oxygen supply.

Question 3

Angina is a disease - T/F?

Answer 3

False - it is a symptom of a disease!

Question 4

What are the therapy objectives for Angina?

Answer 4

Prevent Myocardial Infarction and death and prevent myocardial ischemia and pain.

Question 5

What are the factors that contribute to oxygen demand?

Answer 5

Heart rate, myocardial infarction, intra-myocardial wall tension. .

Question 6

What are the factors that contribute to Oxygen supply?

Answer 6

Myocardial blood flow/coronary vessels.

Question 7

Under normal conditions, almost all oxygen is removed from coronary arterioles by heart. T/F?

Answer 7

True

Question 8

When oxygen demand increases, coronary arterioles….

Answer 8

dilate to increase flow.

Question 9

Myocardial coronary flow occurs only during….

Answer 9

diastole, since the vessels are squeezed shut when heart contracts.

Question 10

What are the three types of Angina Pectoris?

Answer 10

1. Chronic stable angina (Exertional.)
2. Variant Angina (Prinzmetal’s)
3. Unstable Angina

Question 11

Chronic Stable Angina (Exertional Angina) - CAD - triggered by…

Answer 11

increase in physical activity, emotional excitement, large meals, and cold exposure.

Question 12

What is the treatment for Chronic Stable Angina?

Answer 12

Organic Nitrates, Beta Blockers, Ca++ channel blockers, antiplatelete drugs.

Question 13

Variant Angina - caused by…

Answer 13

artery spasm.

Question 14

What are the drugs to treat Variant Angina ?

Answer 14

Ca ++ channel blockers, organic nitrates.

Question 15

Severe Coronary Artery Disease - due to…

Answer 15

vasospasm, platelet aggregation, transient coronary thrombi/emboli.

Question 16

What is the treatment for severe CAD? (non-drug.)

Answer 16

Maintain oxygen supply, decrease oxygen demand.

Question 17

What is the drug therapy treatment for Severe CAD?

Answer 17

Anticoagulants, Nitrates, Beta Blockers, Calcium Channel Blockers, Morphine.

Question 18

Nitrates - relieve angina by causing ___.

Answer 18

Vasodilation.

Question 19

Beta Blockers - provide sustained protection against ….

Answer 19

effort induced angina.

Question 20

Beta Blocker - therapeutic effect comes from ___ of beta receptors in heart.

Answer 20

Blockage.

Question 21

Calcium Channel Blockers (Verapamil) - result in…

Answer 21

arteriole dilation. It treats both stable and variable angina.

Question 22

What are the surgeries to help angina?

Answer 22

CABG and MIDCAB and PTCA! CABG - Coronary Artery Bypass Graft Surgery and MIDCAB - Minimally Invasive Coronary Artery Bypass Surgery, and PTCA - Percutaneous Transluminal Coronary Angioplasty