Neuro System Biochemistry 1 Flashcards
What nutritional deficiencies are associated with dementia and encephalopathy?
Vitamin B12, niacin, thiamine and folate. These cofactors are necessary for proper neural function.
What nutritional deficiency is associated with seizures?
Pyridoxine
What nutritional deficiencies are associated with myelopathy?
Vitamin B12, Vitamin E, and folate
What nutritional deficiencies are associated with peripheral neuropathy?
Thiamine, Vitamin B12 & E, pyridoxine, and folate
What nutritional deficiencies are associated with optic neuropathy?
Vitamin B12, thiamine, and folate
What 2 biochemical reactions depend on Vitamin B12?
(1) Conversion of methylmalonic acid to succinyl Co-A
(2) A co-factor in the conversion of homocysteine to methionine
What is methionine used for in the nervous system?
It is converted into S-adenosylmethionine sam
What other vitamin is essential in the production of methionine, sam, and tetrahydrofolate?
Folate
Thiamine is the precursor for what co-enzyme?
Thiamine pyrophosphate, which helps produce coenzyme A
Besides Beriberi what other syndrome is associated with thiamine deficiency?
Wernicke-korsakoff syndrome. This condition manifests in symptoms such as diplopia, ptosis, confusion, and ataxia.
Overdose of Vitamin A results in what neurological symptoms?
Pseudotumor cerebri with headaches and papilledema. Pseudotumor cerebri is a condition due to intracranial hypertension.
When deficient what mineral can cause myelopathy?
Copper
From what amino acid can the body produce tyrosine?
Phenylalanine
What is the rate limiting step in the conversion of tyrosine to L-dopa?
Tyrosine hydroxylase. This enzyme utilizes tetrahydrobiopterin and oxygen.
What vitamin is necessary for the conversion of L-DOPA to dopamine?
Vitamin B6
