Immunological System Pathology 1 - Mycology Flashcards

1
Q

What is the common name for the clinical presentation of Coccidiodes immitis or Coccidiodes posadasii infection?

A

San Joaquin Valley fever, formally coccidioidomycosis

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2
Q

From what do fungi derive their energy, and how is this different from plants?

A

From organic chemicals, primarily saccharides, unlike photosynthesis in most plants.

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3
Q

Residence in what region of North America is a risk for contracting coccidioidomycosis?

A

Southwestern US, Northwestern Mexico, and Central America

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4
Q

Residence in what region of North America is a risk for contracting histoplasmosis?

A

Northeastern US in Ohio and Mississippi river valleys

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5
Q

Residence in what region of North America is a risk for contracting Blastomycosis?

A

States bordering the Mississippi and Ohio rivers and those states and provinces bordering the Great Lakes and St. Lawrence River

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6
Q

What is the most common clinical presentation for someone infected with Coccidiodes immitis?

A

Flu-like illness (fever, chest pains, cough, and weight loss)

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7
Q

Who is most likely to develop serious complications or meningial involvement if infected with Coccidiodes immitis?

A

Immunodeficient individuals, pregnant women, those with blood group B, and those of African and Filipino descent

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8
Q

What are the acute symptoms of a Blastomy-cosis infection?

A

Looks like a bacterial pneumonia (myalgia, arthralgia, chills, fever, and cough) potentially with bone, skin, or male genitourinary involvement

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9
Q

What are the acute symptoms of a Histoplasmosis infection?

A

Mild flu-like illness (fever, headache, malaise, pleuritic chest pain, and nonproductive cough)

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10
Q

Which primary fungal infection has primary lung involvement with secondary mucosal lesions?

A

Paracoccidioidomycosis cause by Paracoccidioides brasiliensis

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11
Q

How do yeast reproduce?

A

Asexual budding

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12
Q

How do molds reproduce?

A

Spores, can be formed by meiosis (sexually) or mitosis (asexually)

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13
Q

What is the tubular branching network of a mold technically called?

A

Mycelium or colony

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14
Q

What is the name of the tubular branches of a mold

A

Hyphae and Pseudohyphae

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15
Q

What are the two types of Hyphae?

A

Coenocytic (hollow and multinucleate)

Septate (Septate contains groups of cells surrounded by a tubular cell wall and divided by a porous septum which allows for the sharing of cytoplasm and organelles)

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16
Q

How do pseudohyphae and hyphae differ?

A

Pseudohyphae do not share cytoplasm or organelles between cells

17
Q

Do yeast contain hyphae?

A

No, they are unicellular

18
Q

How can a mold be differentiated from a yeast under the microscope, and can an organism switch between the two forms?

A

Mold has hyphae, yeast are single rounded cells; and organism can switch between them or at least go between a yeast form and a pseudohyphae-forming form.

19
Q

What substance predominates in the fungal cell wall?

A

Chitin

20
Q

What steroidal substances predominates in the fungal plasma membrane?

A

Ergosterol. This serves a similar function of cholesterol in animal cells.

21
Q

What medically important fungus is an obligate anaerobe?

A

None! (unlike bacteria)

22
Q

What primary fungal pathogen is associated with bat and bird feces?

A

Histoplasma capsulatum

23
Q

What opportunistic fungal pathogen is associated with bird feces?

A

Cryptococcus neoformans

24
Q

What large capsulated yeast is commonly found in pigeon droppings?

A

Cryptococcus neoformans

25
Q

Dermatophytes survive by obtaining nutrients from what?

A

Keratin

26
Q

How is Tinea diagnosed?

A

Koh wet mount, Wood’s light or Fungal culture

27
Q

How is Candida diagnosed?

A

Gram stain, Koh wet mount, vaginal pH, and skin biopsy

28
Q

What opportunistic yeast most commonly overgrows in immunocompromised patients?

A

Candida albicans

29
Q

How do you differentiate between a cutaneous Candida and Tinea infection?

A

Candida affects skin folds and the scrotum and has satellite lesions versus Tinea corporis doesn’t affect skin folds and Tinea crusis doesn’t affect the scrotum

30
Q

What organisms cause jock itch (tinea cruris)?

A

Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum

31
Q

What organism causes tinea barbae?

A

Trichophyton verrucosum

32
Q

Chronic histoplasmosis can clinically resemble what other infectious disease?

A

Tuberculosis

33
Q

What is the purpose of adding potassium hydroxide (koh) to wet mounts?

A

Dissolves human skin while leaving yeast cells intact.

34
Q

What is the purpose of using India Ink?

A

It is used primarily to detect Cryptococcus spps.