Immunological System Pathology 1 - Virology Flashcards
What lymphoid cell is most affected by Epstein-Barr virus (EBV)?
B lymphocytes
What two diseases are associated with EBV?
Infectious mononucleosis
Chronic fatigue syndrome
What infection is defined by the appearance of multinucleated giant cells with intranuclear inclusions inside organ tissues?
Cytomegalovirus (CMV)
How is EBV distinguished from CMV?
Monospot test for EBV (heterophile antibodies) or by detecting anti-cmv IgM in a blood sample
What is the gold standard test for CMV?
Tissue culture
What is the characteristic finding found in tissue staining for CMV?
“Owl’s eyes” bodies, otherwise known as basophilic intranuclear inclusion body surrounded by a clear halo.
Human herpes virus-6 is associated with what exanthum?
Roseola infantum
Roseola infantum is associated with what characteristic macular rash? What other virus can cause this?
The slapped cheek rash; parvovirus B19 (a.k.a. erythrovirus B19)
What are the four pathogenic viruses in the Paramyxovirus family?
Measles
Mumps
Respiratory syncytial virus (rsv)
Parainfluenza viruses.
What virus is associated with German measles?
Rubella
What is the incubation period of rubella?
14-21 days
Rubella infection is associated with what outcome if contracted by pregnant women?
Congenital malformation in the heart, the eyes, and/or brain in the fetus in the first trimester.
How is rubella spread?
Respiratory droplets
What is the name of the virus that causes measles?
Rubeola
What skin presentation is virtually diagnostic for measles? Where does it appear? What does it look like?
Koplik’s spots on the buccal mucosa; bright red lesions with a white center.
What is the incubation period for measles?
7-14 days.