mitochondria Flashcards
what do mitochondria contain?
- their own DNA
- two membranes
what do mitochondria do?
- move around the cell
- only produce some proteins they need
- produce ATP
- undergo fission and fusion events
In mitochondrial disease, the fault mitochondria are inherited from…
the mother
what are the regions/areas/parts/domains/spaces/membranes of the mitochondria?
- crista junction
- crista membrane
- crista space
- cristea
- inner membrane
- inter membrane space
- matrix
- outer membrane
what happens during energy production in the mitochondria?
the flow of protons through ATP-synthase generated ATP
features of pmf during energy production in mitochondria
- consists of the proton gradient and the pH gradient
how do protons move
down pH gradient
across the membraned due to difference in membrane potential
how does membrane potential effect pmf
contributes more to the proton motive force (PMF) than the pH gradient
What carries electrons from the Krebs cycle (aka Citric Acid; TCA) to the electron transport chain?
NADH
What are inputs for energy production in the mitochondria?
ADP
O2
acetyl CoA
What are outputs of energy production in the mitochondria?
ATP
CO2
H2O
True or false? The mitochondria use the same genetic code as the rest of the cell?
false
In a three-parent baby (mitochondrial replacement therapy), which of the following would be true?
- The germ-line of the resulting baby is permanently changed, that is, it will no longer have the same mtDNA as the mother
- The mitochondria of the mother carried a faulty gene and hence needed replacing
- The resulting baby will have genomic DNA derived from the mother and the father
- the resulting baby will have the same genomic DNA derived from the mother and father, and different mtDNA, compared to the mother
