catalytic strategies Flashcards
what is an acid-base catalysis
An enzyme that accepts H + from hydronium and transfers it to an amino group of the substrate.
the result is an increase in the rate of release of the product. T
what does carbonic anhydrase use?
acid-base catalysis
catalysis by approximation
metal ion catalysis
what does serine proteases use?
acid-base catalysis
catalysis by approximation
covalent catalysis
what does serine proteases contain?
a serine residue in their active site
what does the catalytic triad of serine proteases contains:
serine, histidine and aspartic acid residues
What metabolic type of reaction involves the addition of a functional group across a double bond or the removal of a functional group to form a double bond?
lyase
what are the features of equilibrium of this reaction?
CO2 + H2O ⇌ H2CO3
- An increase in the concentration of CO 2 will result in a decrease of pH.
- The H2CO3 dissociates to H+ and bicarbonate ion, HCO3–.
- The majority of CO2 is transported to the lungs in the form of HCO3–.
- This reaction is catalysed by carbonic anhydrase.
What is not an internationally accepted class of enzymes?
polymerase
What metabolic type of reaction involves the cleavage of bonds by the addition of water?
hydrolysis
What is the most predominant form for the transfer of carbon dioxide in the blood?
HCO3-
what enzyme does carbonic anhydrase contains in its active site.
Zn2+ ion
what does carbonic anhydrase do?
decreases the pKa of water
