citric acid cycle Flashcards
intermediates in the citric acid cycle are used as precursors in the biosynthesis of what?
amino acids
fatty acids
nucleotides
sterols
what are the alternative names for the citric acid cycle?
krebs cycle
tricarboxylic acid cycle
What enzyme(s) is (are) responsible for the following reaction?
Pyruvate + CoA + NAD+ → acetyl CoA + NADH + H+ + CO2
pyruvate dehydrogenase complex
What is/are the chemical change(s) involved in the conversion of citrate into isocitrate?
dehydration followed by hydration
Where does the citric acid cycle take place in the cell?
mitochondria
Which molecule initiates the citric acid cycle by reacting with oxaloacetate?
acetyl CoA
what is the biochemical role of coenzyme A?
it activates acyl groups for group transfer
what is the net organic products formed during the oxidation of one acetyl group to two molecules of carbon dioxide via the citric acid cycle?
3 NADH + 1 FADH2 + 1 GTP
What is considered a product of the citric acid cycle?
carbon dioxide
Which citric acid cycle metabolites is found at the traditional start and finish of the cycle?
oxaloacetate
When metabolites of the citric acid cycle are depleted by biosynthetic pathways, which reactions are used to replenish the citric acid cycle intermediates?
anaplerotic
In which reaction is GTP (or ATP) directly formed in the citric acid cycle?
conversion of succinyl CoA to succinate
