Integration and regulation of metabolism Flashcards
what are two key regulatory enzymes of the citric acid cycle?
Citrate synthase and the NAD+-specific isocitrate dehydrogenase
what are citrate synthase and the NAD+-specific isocitrate dehydrogenase inhibited by?
ATP and/or NADH.
which enzymes are a key regulatory site in the citric acid cycle?
- pyruvate dehydrogenase
- α-ketoglutarate dehydrogenase
what decreases the entry of acetyl-CoA into the citric acid cycle?
when the ratio of [ATP]/[ADP] is high.
what is the committed step of a metabolic pathway?
It is the first irreversible reaction in the pathway.
What is an allosteric inhibitor of gluconeogenesis?
AMP
What is an allosteric inhibitor of phosphofructokinase?
ATP
In animals what happens to the carbon backbone of glucose?
it can be metabolically converted and utilised for synthesis of fatty acids
in animals, what happens to the carbon backbone of fatty acids?
it cannot be metabolically converted and utilised for synthesis of glucose.
