Lung Cancer Lecture Powerpoint

Question 1

Lung cancer within the lobe of the lung presents as ___, lung cancer on the center of the chest or bronchus presents as ____

Answer 1

pain, cough

Question 2

What is the most commonly diagnosed cancer in men? Women? What cancer most often kills men and women?

Answer 2

Prostate, breast, lung and bronchus

Question 3

Non smokersr who develop lung cancer tend to have genetic alterations encoding….

Answer 3

…epidermal growth factor receptor (EGFR)

Question 4

Lung cancer screening guidelines USPSTF

Answer 4

-Low cost CT for those 55-77 with no symptoms of lung cancer, have 30 pack year smoking history, and if have quit within 15 years

Question 5

If a lung tumor is >__cm, than the 5 year survival rate drops off significantly

Answer 5

2

Question 6

-Non small cell carcinoma lung cancers tend to metastasize to these 2 structures, small cell carcinoma lung cancers tend to go to this structure

Answer 6

• adrenal glands
• mediastinum
• brain

Question 7

Bronchogenic carcinoma

Answer 7

Proliferatory neoplasm arising from primary respiratory epithelium, with 95% being described as either small cell or non small cell

Question 8

Pancoast tumor

Answer 8

Any cancer of the lung that is in the upper lobe and causes horner syndrome and weakness in the hands and shoulder

Question 9

Primary cause of small cell lung cancer

Answer 9

-smoking

Question 10

Lung cancer risk factors (4) What dietary element helps prevent it?

Answer 10

• previous history
• smoking
• family history
• asbestos
• dietary vit A

Question 11

Why does lung cancer cause excessive mucus production?

Answer 11

Death of the ciliated columnar cell that act potentiate the mucociliary escalator can no longer function so goblet cells must hypersecrete to compensate and protect the integrity of the lungs against pathogens

Question 12

Carcinoid tumor secretion and what does it cause?

Answer 12

Excess serotonin (nausea, shivering, diarrhea)

Question 13

Some common presentations of lung cancer (7)

Answer 13

• cough
• vena cava syndrome
• hemoptysis
• chest pain
• dyspnea
• hoarseness
• pneumonia

Question 14

Superior vena cava syndrome treatment (2)

Answer 14

-prednisone and high dose radiation

Question 15

Small cell carcinoma neoplastic presentations (5)

Answer 15

• hypercalcemia
• SIADH
• hypoglycemia
• acanthosis nigricans
• erythema multiforme

Question 16

Eaton Lambert syndrome

Answer 16

Rare autoimmune disorder characterized by impaired Ach release resulting in proximal muscle weakness, decreased DTR’s, and over 50% are associated with thoracic neoplasms seen in small cell lung cancer

Question 17

Benign (noncancerous) causes of solitary pulmonary nodules (3)

Answer 17

• granulomas
• rheumatoid or sarcoidosis
• aspiration

Question 18

Doubling time of lung cancer tumor on CXR

Answer 18

in 20-400 days it will grow rapidly, if benign it will slowly grow if at all, inflammatory will very rapidly (within days, but will resolve)

Question 19

Biopsy of lung cancer techniques (3)

Answer 19

• bronchoscopy in some cases
• Transthoracic needle biopsy #1 choice
• sputum cytology

Question 20

Stage I and II lung cancers can be treated with ___, but stage III and IV require _____

Answer 20

surgery, chemo and radiation