Levetiracetam Flashcards
What is the classification of levetiracetam?
Levetiracetam is classified as an antiepileptic drug (AED).
What is the standard starting dosage of levetiracetam for adults?
The standard starting dosage for adults is typically 500 mg twice daily.
True or False: Levetiracetam is used to treat only partial seizures.
False: Levetiracetam is used to treat partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures.
What is the primary mechanism of action of levetiracetam?
Levetiracetam works by modulating neurotransmitter release through binding to the synaptic vesicle protein SV2A.
Fill in the blank: Levetiracetam is indicated for the treatment of ________ seizures.
epileptic
What are common adverse effects of levetiracetam?
Common adverse effects include drowsiness, fatigue, and dizziness.
Which of the following is a serious adverse effect of levetiracetam? A) Rash B) Suicidal thoughts C) Nausea
B) Suicidal thoughts
Levetiracetam should be used with caution in patients with ________ impairment.
renal
What is the maximum recommended daily dosage of levetiracetam for adults?
The maximum recommended daily dosage is 3000 mg.
True or False: Levetiracetam interacts with the cytochrome P450 system.
False: Levetiracetam has minimal interactions with the cytochrome P450 system.
What should be monitored in patients taking levetiracetam?
Patients should be monitored for mood changes and signs of depression.
Fill in the blank: Levetiracetam is often used as an adjunctive therapy for ________ epilepsy.
partial-onset
What is the mechanism by which levetiracetam reduces seizure activity?
Levetiracetam reduces seizure activity by inhibiting excessive neurotransmitter release.
Which population requires a dosage adjustment when taking levetiracetam?
Patients with renal impairment.
What is a common initial side effect that may improve over time when taking levetiracetam?
Drowsiness.
True or False: Levetiracetam can be abruptly discontinued without risk.
False: Abrupt discontinuation can increase the risk of seizures.
Fill in the blank: Levetiracetam is contraindicated in patients with a history of ________ hypersensitivity.
levetiracetam
What is the typical titration schedule for levetiracetam?
Titration is typically done by increasing the dose by 500 mg every two weeks.
What are some potential drug interactions with levetiracetam?
Levetiracetam has minimal drug interactions but should be used cautiously with other CNS depressants.
Fill in the blank: Levetiracetam is available in ________ form.
oral and intravenous
What is the significance of the SV2A protein in the action of levetiracetam?
SV2A is a synaptic vesicle protein that levetiracetam binds to, modulating neurotransmitter release.
True or False: Levetiracetam can be used in pediatric patients.
True: Levetiracetam is approved for use in pediatric patients.
What is one of the advantages of levetiracetam compared to other antiepileptic drugs?
Levetiracetam has a favorable side effect profile and minimal drug interactions.
What is the importance of gradual dosage adjustment when prescribing levetiracetam?
Gradual adjustment helps minimize the risk of adverse effects and seizure exacerbation.
