Clopidogrel Flashcards
What is the classification of clopidogrel?
Clopidogrel is classified as an antiplatelet medication.
What is the usual adult dosage of clopidogrel for the prevention of cardiovascular events?
The usual adult dosage is 75 mg orally once daily.
What is the primary action of clopidogrel?
Clopidogrel inhibits platelet aggregation by blocking the ADP receptor on platelets.
True or False: Clopidogrel is indicated for the treatment of acute coronary syndrome.
True.
Fill in the blank: Clopidogrel is often prescribed after ________ to prevent thrombosis.
stent placement
What are the common adverse effects of clopidogrel?
Common adverse effects include bleeding, bruising, and gastrointestinal upset.
What serious adverse effect is associated with clopidogrel?
Thrombotic thrombocytopenic purpura (TTP) is a serious adverse effect.
What drug interaction should be monitored when a patient is on clopidogrel?
The interaction with proton pump inhibitors (PPIs) should be monitored.
True or False: Clopidogrel can be used in combination with aspirin.
True.
What should be considered before starting clopidogrel in a patient?
Consider the patient’s risk of bleeding and liver function.
What is the mechanism of action of clopidogrel?
Clopidogrel is a prodrug that requires metabolic activation to inhibit the P2Y12 receptor on platelets.
Multiple choice: Which of the following is NOT an indication for clopidogrel? A) Stroke prevention B) Post-myocardial infarction C) Hypertension D) Peripheral artery disease
C) Hypertension
What is the loading dose of clopidogrel in acute coronary syndrome?
The loading dose is typically 300 mg to 600 mg orally.
Fill in the blank: Clopidogrel is often used in patients with ________ to reduce the risk of heart attack.
atherosclerosis
What monitoring is recommended for patients on clopidogrel?
Monitoring for signs of bleeding and regular blood counts.
True or False: Clopidogrel is contraindicated in patients with active bleeding.
True.
What is a potential effect of clopidogrel on platelet function?
Clopidogrel can lead to prolonged bleeding time.
What dietary consideration should patients on clopidogrel be aware of?
Patients should avoid excessive intake of garlic and ginkgo biloba, which may increase bleeding risk.
What is the effect of clopidogrel on cardiovascular events?
Clopidogrel reduces the risk of myocardial infarction and stroke.
What is the duration of action of clopidogrel?
The duration of action is approximately 5 to 7 days after discontinuation.
What is a key consideration regarding the genetic variability of clopidogrel?
Some patients have genetic polymorphisms affecting the metabolism of clopidogrel, impacting its efficacy.
What is the recommended action if a patient experiences major bleeding while on clopidogrel?
Discontinue clopidogrel and manage the bleeding appropriately.
Multiple choice: Which of the following is a contraindication for clopidogrel? A) History of TTP B) Diabetes C) Hypertension D) Hyperlipidemia
A) History of TTP
What is the impact of clopidogrel on platelet aggregation?
Clopidogrel significantly reduces platelet aggregation.
