Intravenous anesthetics 2 Flashcards
Ketamine: (select 3)
a. causes emergence delirium
b. agonizes the N-methyl-D-aspartate receptor
c. relieves somatic pain
d. increases the risk of depression
e. increases the cerebral metabolic rate of oxygen consumption
f. promotes bronchoconstriction
a. causes emergence delirium
c. relieves somatic pain
e. increases the cerebral metabolic rate of oxygen consumption
What is the primary mechanism of action of ketamine?
NMDA antagonist (creates a dissociated state)
What is the secondary mechanism of action of ketamine?
many secondary receptor targets including opioid, MAO, serotonin, NE, muscarinic, and Na+ channels
What is the onset of IV ketamine?
30-60 seconds
What is the onset of IM ketamine?
2-4 minutes
What is the onset of PO ketamine?
variable
What is the duration of action of ketamine?
10-20 minutes (may require 60-90 minutes to return to full orientation
What is the clearance of ketamine?
liver
What is the active metabolite of ketamine?
norketamine
What is the IV, IM, and PO induction doses of ketamine?
IV: 1-2 mg/kg
IM: 4-8 mg/kg
PO: 10 mg/kg
What is the opioid sparing dose of ketamine?
0.1-0.5 mg/kg or 1-3 mcg/kg/min.
What are the respiratory effects of ketamine?
maintains respiratory drive, increased oral secretions, bronchial dilation
What are the CV effects of ketamine?
Increased SNS tone, SVR, HR, and Cardiac output
increased pulmonary vascular resistance
What are the CNS effects of ketamine?
increased ICP, IOP, nystagmus, and analgesia
also causes emergence delirium & lowers the seizure threshold
Subhypnotic doses of ketamine may be used to
treat severe depression
Ketamine should be avoided with
acute intermittent porphyria
What is the pKa of ketamine?
7.5
Ketamine works by
dissociating the thalamus (sensory) from the limbic system (awareness)
Chronic ketamine use _______ the enzymes that metabolize it
induces