ANS pharmacology & pathophysiology 4 Flashcards
Which is NOT a competitive inhibitor of acetylcholine?
a. atropine
b. nicotine
c. scopolamine
d. glycopyrrolate
b. nicotine
Cholinergic agonists mimic the actions of
ACh but differ in their nicotinic and muscarinic activities
Muscarinic antagonists like atropine are
competitive inhibitors of ACh at parasympathetic muscarinic receptors
Side effects of muscarinic antagonists include
tachycardia
dry mouth
decreased GI motility
bronchodilation
A common self-administered cholinergic agonist is
nicotine
Ganglia of __________ are activated by nicotine
the SNS and PNS
In the CV system, nicotine’s effects lead to
unopposed sympathomimetic activity causing the vascular tone to increase
Other examples of cholinergic agonists include
methacholine
bethanachol
carbamychloline
pilocarpine
Methacholine is used as a provocative agent to identify
reactive airway disease in those who do not have clinically apparent signs of asthma
Methacholine evokes
bronchoconstriction
increases airway secretions
impairs peak expiratory flow rates via M3
Bethanachol is relatively selective for
M3 receptors in the GI and urinary tracts and is used to treat nonobstructive urinary retention in the perioperative period
Carbamylcholine and pilocarpine produce
miosis and have applications in treating glaucoma
What is the specificity of atropine, glycopyrrolate, and scopolamine?
little to no muscarinic subtype specificity
Low does atropine (<0.1 mg) may cause or worsen
bradycardia by blocking presynaptic M1 receptors
Muscarinic antagonist effects of atropine dose 0.5-1.0 mg:
increased HR
dry mouth
lack of sweating
feeling thirsty
pupillary dilation
Muscarinic antagonist effects of atropine dose 2-5 mg:
tachycardia
palpitations
mydriasis
cycloplegia
restlessness
confusion
Muscarinic antagonist effects of atropine dose >5 mg:
profound tachycardia
mydriasis
cycloplegia
hot flushed skin
fever hallucinations
coma
death
What should be given in the setting of atropine overdose?
physostigmine 1-2 mg IV b/c it will cross the BBB
What effect does diltiazem have on the AV node?
a. sympathomimetic
b. negative inotropic
c. positive inotropic
d. negative dromotropic
d. negative dromotropic