Coagulation 8 Flashcards
Triggers of sickle cell crisis include: (select 2)
a. alkalosis
b. hyperthermia
c. pain
d. dehydration
c. & d.
Sickle cell disease is a _________ disorder that affects __________
inherited; erythrocytes
Sickled cells are more prone to _________
hemolysis and removal by the spleen
What is the average lifespan of sickled cells compared to normal cells
12-17 days vs. 120 days
______________ leads to sickling
deoxygenation of HgbS
Sickling causes the RBCs to ___________ which causes __________
clump together; mechanical obstruction of the microvasculature in the vital organs and joints
What factors can trigger a sickle-cell crisis?
pain
hypothermia
hypoxemia
acidosis
dehydration
Complications of sickle cell crisis include
vaso-occlusive crisis, acute chest syndrome, & sequestration crisis
The most common manifestation of sickle cell disease is
vaso-occlusive crisis
Treatment of vaso-occlusive crisis includes
analgesics and hydration
As a general rule, patients with sickle cell ______ do not advance to crisis. _________ is a key exception to this rule.
TRAIT; Severe hypoxemia
____________ reduces the incidence and severity of vaso-occlusive crisis
Hyroxyurea
Acute chest syndrome is caused by
thrombosis, embolism, and infection
Diagnosis of acute chest syndrome includes
new lung infiltrates on the CXR and at least one of the following: chest pain, cough, dyspnea, or wheezing
Potential causes of acute chest syndrome include
hypoventilation
narcotics
splinting
pain