Inhaled anesthetics 2: Pharmacodynamics 3 Flashcards
Sevoflurane at 1.5 MAC increases:
a. cerebral metabolic rate of oxygen
b. cerebral blood volume
c. cerebral vascular resistance
d. cerebrospinal fluid production
b. cerebral blood volume (volatile anesthetics supply the brain with more blood flow than it needs)
What level of MAC is required to produce an isoelectric state?
1.5-2.0 MAC
How do halogenated anesthetics impact CMRO2?
dose-dependent reduction in CMRO2
How do halogenated agents impact cerebral blood flow?
dose-dependent increase in CBF
How do halogenated agents impact cerebral blood volume?
dose-dependent increase
How do halogenated agents impact ICP?
dose-dependent increase
___________ in high concentrations (2.0) MAC can produce seizure activity.
Sevoflurane
Sevoflurane’s ability to produce seizure activity in high concentrations is exacerbated by
hypocapnia & is more common with inhalation induction
How does nitrous oxide impact CMRO2?
increases CMRO2
How does nitrous oxide impact cerebral blood flow?
increases CBF
Which volatile anesthetic increases CSF production?
desflurane
CMRO2 is dependent on:
electrical activity (60% of total brain oxygen consumption)
cellular homeostasis (40% of total brain oxygen consumption)
What impact do volatile anesthetics have on cerebral vascular resistance?
cerebral vasodilators (they decrease CVR)
Desflurane affects somatosensory evoked potentials by:
a. increasing amplitude and increasing latency
b. increasing amplitude and decreasing latency
c. decreasing amplitude and increasing latency
d. decreasing amplitude and decreasing latency
c. decreasing amplitude and increasing latency
_______ are most resistant to the effects of anesthetics
brain auditory evoked potentials