GI Meds 3 Flashcards
Where is H. pylori often present?
- upper GI tract
- in people with gastric ulcer disease
Does H. pylori have a role in gastric ulcer formation?
exact role is uncertain
tx of H. pylori in gastric ulcer disease
- several protocols
- all use multidrug therapy
H. pylori tx: usually consists of
- mixture of antibiotics and PPIs
H. pylori tx: timeframe
- administered for 10-14 days
- maintenance on a PPI
GI complications of NSAIDs: overall
very few toxic complications, but they can have significant effects on the entire GI tract
GI complications of NSAIDs: most commonly affects
gastroduodenal mucosa
GI complications of NSAIDs: major complications can result in
life-threatening bleeding and perforation
How do NSAIDs work?
- nonselectively inhibit actions of COX 1 and 2 inhibitors
- get full anti-inflammatory effect but at the cost of the GI system
CNS changes with NSAID-induced disease
- HA
- confusion
- memory loss
- mood changes
NSAID-induced disease: these s/s would implicate renal involvement
- mm weakness
- unusual fatigue
- nocturia
- RLS
NSAID-induced disease: general s/s
- can be asymptomatic
- stomach upset/pain
- indigestion/heartburn
- skin rxns
- increased BP
- new onset back/shoulder pain
- melena
- tinnitus
risk factors for NSAID-induced gastropathy
- over 65
- hx of peptic ulcer or GI disease
- smoking, alcohol use
- anticoagulation
- acid suppressants
- NSAIDs combined with SSRIs
Why is use of acid suppressants a risk factor for NSAID-induced disease?
can mask the warning sx
GI meds to know
- Reglan
- Cytotec
- Carafate and Sulcrate
- anti-diarrheal agents
- laxatives and cathartics
- emetics, antiemetics
