GI 6 Flashcards

1
Q

Malabsorptive disorders are a result of

A

myriad of diseases that have malabsorption of nutrients as a consequence

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2
Q

malabsorptive disorders: typically affect this

A

small intestine (where most nutrients are absorbed)

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3
Q

malabsorptive disorders: conditions

A
  • celiac disease
  • infections
  • short gut syndrome 2˚ to surgery
  • structural defects
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4
Q

What is the most common malabsorptive disorder?

A

celiac disease

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5
Q

What is celiac?

A
  • immune-mediated disorder

- triggered by exposure to gluten

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6
Q

prevalence of celiac

A

~ 1% of population

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7
Q

celiac risk factors

A
  • other autoimmune disorders
  • IgA deficiency
  • genetic syndromes
  • family hx
  • DM I
  • thyroiditis
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8
Q

celiac disease pathogenesis: What happens when the small intestine is exposed to gluten?

A
  • immune response triggered
  • T cells aggregate into small intestine mucosa
  • inflammatory response leads to destruction of intestinal cells
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9
Q

celiac disease is linked to a higher risk of:

A

cancer

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10
Q

celiac dz: s/s

A
  • broad range (makes dx difficult)
  • severe diarrhea, bloating, indigestion
  • WL
  • abd cramping
  • nutrient deficiency
  • long-term complications
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11
Q

celiac dz: nutrient deficiency

A
  • folate
  • iron
  • fat-soluble vitamins
  • Vitamin B12
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12
Q

celiac dz: long-term complications

A
  • OP
  • infertility
  • coagulation abnormalities
  • anemia
  • neuro probs
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13
Q

skin manifestations of celiac

A

dermatitis herpetiformis

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