Flesh- Eating Disease

Question 1

flesh-Eating disease

if lash

flesh

Answer 1

Group A Streptococcal

Question 2

Signs and Symptoms

Answer 2

1- very serious
2- severe pain at wound site
- sometimes without obvious break in skin
3- within short time, swelling ,overlying skin stretched & discolored
4- fever
5- confusion
6-can have fatigue & vomiting
7-necrotizing fasciitis can progress rapidly

fa she itis

fas ci itis

Question 3

Causative Agent

Answer 3

Streptococcus pyogenes

Question 4

necrotizing fasciitis can progress rapidly (within hours)
so we need :

Answer 4

(1) need immediate treatment
(2) patient can go into shock & die

Question 5

pathogenosis

Answer 5

1-M protein & fibronectin binding proteins
-help colonize wound
-evade phagocytosis
2-strains
-cause necrotizing fasciitis
-produce variety of exotoxins
3-variety of enzymes
-help it spread by destroying subcutaneous fascia, fatty tissue, & sometimes muscle tissue such as :
1- streptokinase/fibrinolysin: breaks down blood clots
2- hyaluronidases: break down connection between cells
3- deoxyribonucleases: destroy DNA
4- streptolysins O &S: damage WBCs & RBCs

Question 6

type of enzyme :

Answer 6

1- streptokinase/fibrinolysin: breaks down blood clots
2- hyaluronidases: break down connection between cells
3- deoxyribonucleases: destroy DNA
4- streptolysins O &S: damage WBCs & RBCs

s trap to ki n ase/fi bro nil ice n/hi low rohnd a sis

strepto kin ase/fibrinolysin/hy alu ron id ases

Question 7

risk of developing invasive infection increased with:

Answer 7

(1) chronic diseases (diabetes, alcoholism)
(2) weakened immune system (cancer, AIDS)
(3) skin wounds (trauma, burns, surgery)

Question 8

Epidemiology

Answer 8

1-cases in US rare & sporadic
2- invasive infections seldom occur in healthy people with minor injuries

S pir aad ik=متقطع/ sall dimنادر

spor adic/ sel dom

Question 9

Treatment

Answer 9

1-surgery
2-IV antibiotics but have no effect on:

Question 10

surgery

Answer 10

(1) relieve pressure
(2) remove dead tissue (debridement)
(3) may need to amputate to quickly remove source of toxins

Aam pu tate

Question 11

IV antibiotics but have no effect on:

Answer 11

(a) toxin
(b) necrotic tissue