Feline diseases Flashcards
What is FeLV?
Feline leukaemia virus
What is FIV?
Feline immunodeficiency virus
What category of virus are FeLV and FIV?
Retroviruses
What is the prevalence of FeLV and FIV?
FeLV - 3% of shelter cats
FIV - 11% of shelter cats
What type of signalment of cat is FeLV normally found in?
Adult cats
Clinically ill
What type of signalment of cat is FIV found in?
Adult males (neutered or entire) With outdoor access
How is FeLV transmitted?
Close prolonged contact
Oronasal exposure to infected saliva
How is FIV transmitted?
Biting and fighting
Infected saliva and blood
How does transmission of FeLV and FIV compare?
FeLV - friendly virus
FIV - unfriendly virus
What does abortive exposure to FeLV mean?
Virus is overcome - immune system gets rid of the virus before it becomes a problem
What are the two different forms of FeLV infection?
Transient viraemia
Persistent viraemia
What is a transient viraemia?
Virus is overcome but after a while (4 weeks)
Bone marrow will be infected after 3 weeks
What is FeLV infection of the bone marrow called?
Latent infection - provirus is present
What is a persistent viraemia?
Lifelong infection
Poor prognosis
How is the pathogenesis of FIV different to FeLV?
Do not recover from FIV infection
Can recover from FeLV
What are the stages of FIV infection?
Primary infection - first few weeks, mild illness
Asymptomatic period
May have recurrent infections - feline AIDS
What are the main clinical signs of FeLV?
Immunosuppression
Anaemia - regen and non-regen
Neoplasia
What are the main clinical signs of FIV?
Immunosuppression Anaemia Chlamydia felis Herpes virus Chronic rhinitis Stomatitis/gingivitis
How do you diagnose FeLV?
ELISA
PCR
Immunoflorescence
What is detected in the FeLV test?
Antigen - p27
How do you tell if it is a transient/regressive FeLV infection or persistent/progressive FeLV infection?
Retest after 4 weeks
How do you diagnose FIV?
ELISA
PCR
What is detected in the FIV ELISA test?
Antibodies - p24
How do you test kittens born to an FIV infected queen?
Test after 6 months old due to maternally derived antibodies
What is detected in the FIV PCR test?
Provirus
When are false positives for FeLV and FIV a worry?
In healthy cats - 50% likely to be a false positive
only 10% likely to be a false positive in sick cats
How do you treat FIV?
Treat secondary infections
Treat lymphomas with chemo/radiotherapy
AZT - stomatitis/gingivitis
How do you treat FeLV?
Treat secondary infections
Treat lymphomas with chemo/radiotherapy
How do you prevent FeLV and FIV?
Keep indoors, neuter, separate
Vaccinate for FeLV - non core vaccine
No vaccine for FIV
What is the prognosis of FeLV?
85% of viraemic cats die in less that 3 years
What is the prognosis of FIV?
Often can survive many years with good healthcare
What are the most important causes of cat flu?
FHV-1 - feline herpes virus
FCV - feline calicivirus
How long does FHV survive in the environment?
18 hrs - enveloped
How long does FCV survive in the environment?
Fairly labile - 7-10 days but up to a month - non-enveloped
How are FHV and FCV transmitted?
Via nasal, oral and conjunctival routes
What are the two periods of FHV infection?
Latency
Intermittent shedding - 1-2 weeks
When are cats infectious with FCV?
Shedding of virus is persistent/continuous
No latency
What are the clinical signs of FHV?
Rhinitis
Pharyngitis/laryngitis
Dendritic ulcers
Facial dermatitis
What are the clinical signs of FCV?
Lingual ulcers
Chronic gingivostomatitis
Respiratory - cat flu
Fever, anorexia
What is the mortality of systemic FCV?
30-50%
How do you control FHV and FCV?
Vaccinate - doesnt prevent infection, but reduces severity of clinical disease
When should you vaccinate against FHV/FCV?
1st - 8 weeks
2nd - 12 weeks
Ideally 3rd - 16 weeks
When should you booster vaccinate?
Every 1-3 years depending on risk
What is the most common cause of conjunctivitis in cats?
Chlamydia felis
How good is chlamydia felis at surviving in the environment?
Only a few days - obligate intracellular pathogen
How is chlamydia felis transmitted?
From ocular secretions
How long are animals infectious for chlamydia felis?
Prolonged shedding - up to 18 months
What are the clinical signs of chlamydia felis?
Conjunctivitis
Ocular discharge
Chemosis - swollen conjunctiva
Not corneal ulceration - more likely to be FHV
How do you diagnose chlamydia felis?
PCR
How do you treat chlamydia felis?
Tetracyclines - doxycycline
Prolonged systemic treatment
How can you prevent chlamydia felis?
Vaccinate - non core, yearly, reduces severity
How common is infection of cats with bordetella bronchiseptica?
Infection is common but disease is rare
What increases the chances of getting bordetella bronchiseptica?
Dogs in household - kennel cough
How is bordetella bronchiseptica spread in cats?
Nasal and oral secretions
What are the clinical signs of bordetella bronchiseptica?
Respiratory disease
Coughing - destroy cilia
Pneumonia
How do you diagnose bordetella bronchiseptica?
PCR
Culture
How do you treat bordetella bronchiseptica?
Tetracyclines - doxycycline
How can you prevent bordetella bronchiseptica?
Vaccination - non core, uncommon
What type of pathogen is toxoplasma gondii?
Intracellular protozoa
How are cats infected with toxoplasma gondii?
Ingestion of cysts in tissues
Kittens from queen
How long are cats infectious for toxoplasma gondii?
Shed for 10-14 days
After that they develop antibodies and are fine
How long can sporulated oocysts survive in the environment?
18 months
What are the clinical signs of toxoplasma gondii?
CNS signs
Muscle inflammation
Uveitis of eyes
How do you diagnose toxoplasma gondii?
PCR
Serology - IgM
How do you treat toxoplasma gondii?
Clindamycin (macrolide)
Ocular treatment of uveitis
What is the zoonotic risk of toxoplasma gondii?
Human abortion
Immunocompromised
Young/old
How do you reduce zoonotic risk of toxoplasma gondii?
Empty litter trays daily so oocysts cant sporulate
Only feed commercial cat food
Wash hands etc.
What are haemoplasmas?
Epicellular bacteria that attach to the
surface of red blood cells - mycoplasma
What do haemoplasmas cause?
Haemolysis - regenerative anaemia
What type of cats is haemoplasmosis normally found?
Older male outdoor cats - bite history
How is haemoplasmosis diagnosed?
Haematology - regen anaemia
PCR
How do you treat haemoplasmosis?
Doxycycline
Supportive care
What is the prognosis of haemoplasmosis?
Good with prompt treatment
Can become asymptomatic carrier