DIT review - Neurology Flashcards
What neuronal cell is damaged in Guillain-Barre syndrome?
Schwann cells
What neuronal cell is damages in multiple sclerosis
Oligodendrocyte
What cell is the CNS phagocyte?
Microglia
What neuronal cell is involved in reactive gliosis (scar tissue in CNS)?
Astrocyte
What is the embryologic origin of each of the 6 neural cells (neurons, astrocytes, microglia, oligodendrocytes, schwann cells, ependymal cells)?
Neuroectoderm: neurons, astrocytes, oligodendrocytes, ependymal cells
Neural crest cells: schwann cells
Mesoderm: microglia
Layers of the blood-brain barrier
Tight junctions between nonfenestrated endothelial cells of capillaries
Basement membrane
Foot processes of astrocytes
What disease is associated with degeneration of the basal nucleus of Meynert
This is the location of ACh synthesis
Decreased ACh = Alzheimer’s
♣ Supraoptic nucleus
• Produces ADH to be stored in posterior pituitary
♣ Paraventricular nucleus
• Produces oxytocin to be stored in posterior pituitary
♣ Anterior hypothalamus
• Controls cooling (damage = hyperthermia) • Parasympathetic
♣ Posterior hypothalamus
• Controls heating (damage = hypothermia) • Sympathetic
♣ Pre-optic area
• Secretes GnRH stimulates release of LH and FSH
♣ Dorsomedial nucleus
• Stimulates GI • Stimulation = savage behavior and obesity
♣ Arcuate nucleus
• Releases dopamine and GHRH • Regulates hunger and satiety
♣ Mammillary body
• Receives input from hippocampus • Lesions = Wernicke’s encephalopathy