Diagnostics - DUTCH Test

Question 1

What is the DUTCH Test?

Answer 1

The DUTCH (Dried Urine Test for Comprehensive Hormones) is a urine test measuring various hormones and their metabolites.

Question 2

Which laboratories offer the DUTCH Test?

Answer 2

The DUTCH Test is offered by Genova and ZRT.

Question 3

When is the DUTCH Test recommended?

Answer 3

It is recommended for evaluating reproductive hormone imbalances (e.g., low libido, PMS, irregular or painful periods), especially when stress is suspected.

Question 4

What hormones does the DUTCH Test measure?

Answer 4

It tests metabolites of major hormones like estrogen, progesterone, testosterone, and cortisol.

Question 5

What is crucial for accurately interpreting a DUTCH Test?

Answer 5

Knowledge of the patient’s menstrual history and stage (e.g., menopause, pregnancy) and any hormone-altering medications is crucial for accurate interpretation.

Question 6

What do the metabolic pathways in the DUTCH Test indicate?

Answer 6

They indicate potential hormonal disruptions, guiding treatment options. Results are organized by metabolic pathways to identify impacted areas and possible remedies.

Question 7

What are the three main estrogens tested in the DUTCH Test?

Answer 7

The three main estrogens are E1 (Estrone), E2 (Estradiol), and E3 (Estriol).

Question 8

What are the three phase I pathways for estrogen metabolism?

Answer 8

1. 2-OH pathway: Safest due to anti-cancer properties.
2. 4-OH pathway: Most genotoxic, producing reactive DNA-damaging products (quinones).
3. 16-OH pathway: Creates the most potent estrogenic metabolites

Question 9

How does phase II detoxification affect estrogens?

Answer 9

Phase II detoxification can deactivate and eliminate 4-OH and 2-OH estrogens via methylation.