DAT Bio Genetics Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Gene

A

genetic material on a
chromosome for encoding a trait

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Locus

A

location on chromosome where a
gene is located`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Allele

A

alternative forms of a gene that
allow for differences such as different hair
or fur colors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Homologous chromosomes

A

a pair of
chromosomes that contain the same
genetic material
i. Each parent contributes one of the
chromosomes in the pair, thus
allowing for different alleles to be
present for each gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Law of Segregation

A

one member of
each chromosome pair migrates to an
opposite pole in anaphase I so that each
gamete is haploid
i. Basically, each gamete is left with one
copy of each allele

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Law of Independent Assortment

A

the
migration of homologues within one pair
of homologous chromosomes does not
influence the migration of homologues of
other homologous pairs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Monohybrid cross

A

two organisms
with variations at one gene of
interest are crossed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dihybrid cross

A

two organisms with
variations at two genes of interest
on different chromosomes are
crossed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Test cross

A

when the genotype of
an organism expressing the
dominant phenotype is unknown,
the unknown organism is crossed
with a homozygous recessive
organism to determine if the
unknown is homozygous dominant
or heterozygous dominant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Punnett squares

A

technique that
uses probability rules to determine the
outcomes of either monohybrid or
dihybrid crosses and the subsequent
expected frequencies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Incomplete dominance

A

blending of
expressions of alleles

For example, a red flower and white
flower are crossed to result in a
unique heterozygous pink offspring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Codominance

A

both of the inherited
alleles are completely expressed
i. For example, blood types A and B
can show as AB if both are
expressed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Multiple alleles

A

blood groups have
four possible phenotypes, the
codominant A, B, and O, leading to six
possible genotypes and four possible
phenotypes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

AA/AO →

A

type a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

BB/BO →

A

type b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

AB →

A

codominant AB type

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

OO →

A

type O

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Epistasis

A

the process in which one
gene affects the phenotypic
expression of a second gene. A
common example of epistasis is fur
pigmentation in mice → one gene
controls the production of pigment by
either turning on or turning off and the
second gene controls the color or
amount of color deposited in the fur.
Therefore, if the first gene codes for
no pigment, then the second gene has
no effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Pleiotropy -

A

when a single
gene has more than one phenotypic
expression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Polygenic inheritance

A

the interaction
of many genes to shape a single
phenotype with continuous variation
such as height, skin color, or hair color

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Linked genes

A

when two or more
genes reside physically close to one
another on the same chromosome and
therefore cannot separate
independently as they are inherited
together

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Sex-linked genes

A

a type of linked gene
that refers to a single gene residing on a
sex chromosome that is inherited
differently in males and females

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Sex-influenced genes

A

these differ
from sex-linked genes in that the
expression of genes can be influenced
by the sex of the individual carrying the
trait

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Penetrance

A

this concept describes the
probability an organism with a specific
genotype will express a particular
phenotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Complete penetrance means

A

the
genes for a trait are expressed in all
of the population who have the
gene

26
Q

Incomplete penetrance means

A

the
genes for a trait are only expressed
in a percentage of the population

27
Q

Variable Expressivity

A

describes the variation or range of
phenotypes for a specific genotype

28
Q

X-inactivation

A

during embryonic
development in female mammals, one of
the two inherited X chromosomes does
not uncoil into chromatin, and remains as
a dark and coiled compact body, which is
referred to as a Barr body.

29
Q

Nondisjunction

A

describes when one or
more chromosome pairs or chromatids
fail to separate during mitosis. (sister chromatids meiosis ii, homo chromosomes meiosis i)

30
Q

Mosaicism

A

a phenomenon that
occurs in cells that undergo
nondisjunction in mitosis during
embryonic development; fraction of
body cells have extra or missing
chromosomes

31
Q

Polyploidy

A

when all chromosomes
undergo meiotic nondisjunction and
produce gametes with twice the
number of chromosomes

32
Q

Point mutation

A

single nucleotide
change causing either substitution,
insertion, or deletion—the latter two can
cause a frameshift mutation.

33
Q

transition mutation

A

conversion of a purine to purine or
pyrimidine to pyrimidine.

34
Q

transversion mutation

A

conversion of a purine to pyrimidine
or vice versa.

35
Q

Aneuploidy

A

a genome with extra or
missing chromosomes, often caused by
nondisjunction (downs syndrome)

36
Q

Klinefelter’s Syndrome

A

(XXY), in
which a male is born with an extra X
chromosome

37
Q

Chromosomal aberrations

A

chromosome segments are changed

38
Q

duplications

A

chromosome
segments are repeated on the same
chromosome, which can occur from
unequal crossing over

39
Q

Inversions

A

chromosome segments
are rearranged in reverse orientation

40
Q

Translocations

A

one segment of a
chromosome is moved to another
chromosome.

41
Q

Chromosomal breakage

A

spontaneous
or induced breakage of a chromosomal
segment via mutagenic agents or X-rays

42
Q

Mutagenic agents

A

include cosmic rays,
X-rays, UV rays, radioactivity, chemical
compounds including colchicine and
mustard gas that can cause genetic
mutations. Mutagenic agents are
generally also carcinogenic

43
Q

Autosomal recessive conditions (genetic conditions)

A

Phenylketonuria (PKU), Cystic fibrosis, Tay-sachs

44
Q

Phenylketonuria (PKU)

A

inability
to produce the proper enzyme for
phenylalanine breakdown, causing
degradation product
phenylpyruvic acid to accumulate

45
Q

Cystic fibrosis

A

fluid buildup in
respiratory tracts

46
Q

Tay-sachs

A

lysosome defect in
which cells can’t breakdown lipids
for normal brain function

47
Q

Autosomal dominant conditions

A

Huntington’s disease, Achondroplasia, Hypercholesterolemia

48
Q

Huntington’s disease

A

nervous system degeneration

49
Q

Achondroplasia

A

causes dwarfism

50
Q

Hypercholesterolemia

A

excess
cholesterol in blood that
progresses into heart disease

51
Q

Sex-linked recessive conditions

A

Hemophilia, color blindness, Duchenne’s Muscular
Dystrophy

52
Q

Hemophilia

A

sex-linked recessive
genetic condition causing
abnormal blood clotting

53
Q

Color blindness

A

primarily observed in males

54
Q

Duchenne’s Muscular
Dystrophy

A

progressive loss of muscle

55
Q

Chromosomal disorders

A

changes
to the number or structure of
chromosomes

56
Q

Down’s Syndrome

A

trisomy 21

57
Q

Turner’s Syndrome

A

deletion of
X chromosome → XO genotype

58
Q

Cri du Chat

A

deletion on
chromosome 5

59
Q

Extranuclear inheritance

A

extranuclear
genes (genes present in organelles
other than the nucleus) are found in
mitochondria and chloroplasts

60
Q

Lethal gene

A

Imagine we cross Aa x Aa,
and get 1 AA, 2 Aa, and 1 aa. If “aa” is
lethal, our genotypic ratio would be AA
and Aa present in a 1:2 ratio.