CVPR Week 9: Renal tubule disorders Flashcards
Objectives

What’s the diagnosis?

Tubular function! Yay!

What do the renal tubules do?

Hormones affecting salt and water in the renal tubules

How do tubulopathy presents in several ways

Tubulopathy syndromes

What is renal tubular acidosis

Types of RTA

What is RTA
Renal tubular acidosis
Describe normal HCO3- and H+ management

Features of proximal RTA

Describe proximal RTA and HCO3- and H+ management

Distal RTA type 1

Describe distal RTA and HCO3- and H+ management

How to diagnose RTA?

Proximal RTA Urine pH

Distal RTA Urine pH

Urine anion Gap and RTA type

Chronic acidosis leads to?
polyuria, failure to thrive and growth delay
Chronic hypokalemia causes

Calciuria in distal RTA leads to?

RTA has associations with?

Management of RTA

Classification of RTA

RTA diagnosis cheat sheet

Question


Abnormalities of water balance

Volume first?

Diabetes insipidus pathophysiology

Diabetes insipidus symptoms

Diabetes insipidus labs

Describe the normal response to dehydration

Describe the response to dehydration with diabetes insipidus

diabetes insipidus Dx test

diabetes insipidus causes
pituitary or kidney damage, drugs, etc
diabetes insipidus urine output
High urine output
diabetes insipidus urine osmolality
low urine osmolality
diabetes insipidus serum osmolality
High serum osmolality
SIADH AKA
Syndrome of inappropriate anti-diuretic hormone
SIADH description

SIADH blood
low sodium and low osmolality (too much water)
SIADH urine
Low volume and high osmolality (too little water)
SIADH causes
drugs, neurologic dis., surgery, infections, pain, etc.
What happens in SIADH?

What is primary polydipsia?

primary polydipsia blood
low sodium and low osmolality (too much water)
primary polydipsia urine
high volume and low osmolality (too much water)
primary polydipsia causes
- alcoholism
- psychiatric disorders
- athletes
- excessive IV fluids
differentiating water disorders

Question


MEtabolic alkalosis and hyperkalemia

Bartter’s syndrome

Gitelman’s syndrome

hypokalemia and alkalosis + hypertension

Liddle’s syndrome

Hypokalemic alkalosis

Most common cause of hypokalemic alkalosis?

Self-induced metabolic alkalosis

Question


If unexplained Acid-base?

What’s the diagnosis?

