CVPR Week 7: Glomerular Filtration Flashcards
Objectives
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/738/255/a_image_thumb.jpg?1556397936)
Identify
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/738/368/q_image_thumb.png?1556398225)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/738/368/a_image_thumb.png?1556398231)
Identiify
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/738/618/q_image_thumb.png?1556398248)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/738/618/a_image_thumb.png?1556398252)
Location of the glomeruli
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/738/631/a_image_thumb.png?1556398333)
Identify
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/739/067/q_image_thumb.png?1556398470)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/739/067/a_image_thumb.png?1556398477)
What gets through glomerular filtration?
Ultrafiltrate composition
- Proteins and cells excluded at the endothelium
- Electrolytes and small molecules are filtered
- Negatively charged barrier inhibits filtration of negatively charged substances
- Filtrate formed at a rate of 100 to 140
Glomerular filtration rate
filtrate formed at a rate of 100 to 140
Filtrate =
Plasma - proteins (and protein-bound substances)
Average filtrate volume
125 mL/min
180 L/day
What percent of filtrate is reabsorbed?
99% of filtrate is reabsorbed
Starling’s Forces of filtration
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/739/900/a_image_thumb.png?1556398853)
~ Glomerular afferent capillary pressure
60 mmHg
~ Glomerular efferent capillary pressure
60 mmHg
~ Glomerular capillary pressure
afferent to efferent
stays at 60 mmHg
~ Glomerular afferent oncotic pressure
-25 mmHg
~ Glomerular efferent oncotic pressure
-35 mmHg
~ Glomerular oncotic pressure from afferent to efferent
-25 afferent to -35 efferent
so - 10 mmHg difference
~ Bowman’s space afferent oncotic pressure
0 mmHg
~ Bowman’s space efferent oncotic pressure
0 mmHg
~ Bowman’s space oncotic pressure
afferent to efferent
stays at 0 mmHg
~ Bowman’s space afferent hydrostatic pressure
- 15 mmHg
~ Bowman’s space efferent hydrostatic pressure
-15 mmHg