CVPR Week 8: Acid-Base 3 Flashcards by Jay Sandoval

Objectives

How well did you know this?

Not at all

Perfectly

Describe metabolic alkalosis

How well did you know this?

Not at all

Perfectly

Where is aldosterone produced?

by the adrenals (glands that lie on top of the kidneys) in the adrenal cortex in the zona glomerulosa)

How well did you know this?

Not at all

Perfectly

Zones of the adrenal cortex

How well did you know this?

Not at all

Perfectly

What are the stimuli for aldosterone release?

How well did you know this?

Not at all

Perfectly

Types of metabolic alkalosis

How well did you know this?

Not at all

Perfectly

Cl-/saline/volume sensitive metabolic alkalosis

spot urine

Spot urine Cl <10

How well did you know this?

Not at all

Perfectly

Cl-/saline/volume resistant metabolic alkalosis

Spot urine

Spot urine Cl >10

How well did you know this?

Not at all

Perfectly

Pathogenesis of Cl- sensitive metabolic alkalosis

Volume is decreased which results in decreased circulating Cl-
the decreased circulating Cl- is sensed by the macula Densa which triggers synthesis and release of renin and angiotensin 2
Angiotensin 2 increases the activity of the Na/H exchanger in the PCT resulting in H+ loss & increased aldosterone
The increased aldosterone increases the activity of epithelial Na channel (ENaC) causing electrogenic Na+ absorption leading to lumen negativity and K+ loss
The increased K/H activity to absorb more K+ leads to more H+ loss
The lumen becomes more negative and Cl- and HCO3 are not excreted